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Independent Group Leader Opportunities

The Cambridge Stem Cell Institute is a world-leading centre for research in stem cell biology and medicine. The Institute is funded by the Wellcome Trust and the Medical Research Council and currently comprises 27 research groups plus 9 associate groups.

Following a successful quinquennial review, the Institute is seeking new Group Leaders at both junior and senior level to complement and extend our existing programmes. Areas of specific interest for the current call are: (i) physical biology and bioengineering of stem cells; (ii) tissue stem cell biology; (iii) stem cell-based disease modelling and regeneration, in particular for neurological and cardiovascular applications.

Our mission is to make fundamental discoveries in stem cell biology and translate them into biomedical applications. We therefore welcome applications from individuals with expertise in bridging between basic research and medical applications.

Junior group leader candidates will have substantial post-doctoral experience with demonstrable research success and an original research proposal. Senior group leader candidates will have an established reputation for independent high quality research.

The Institute offers excellent core facilities for stem cell culture, ES cell transgenesis, flow cytometry, imaging, and bioinformatics. A start-up package is available and successful candidates will be supported to obtain external personal fellowship and grant support within 1-2 years. Depending on experience you will be appointed to the appropriate grade and salary within the range of £37,012-£62,906.

Informal enquiries are welcome and may be addressed to the Director, Professor Austin Smith ( or any member of the Institute Steering Committee (see

Applicants should send a full curriculum vitae, a 1-2 page outline of research interests, and contact details of three referees to by
19 July 2012.

The University values diversity and is committed to equality of opportunity.

JS_Fig 1

Fig. 1: Inhibitors of the Mek/Erk and GSK3 pathways (2i) in the absence of serum promote the generation of induced pluripotent stem (iPS) cell colonies, shown here. These cells show expression of a pluripotency reporter (green) and reactivation of the silent X chromosome, as demonstrated by the lack of the nuclear red staining body (trimethyl H3K27). For comparison, a cluster of non-reprogrammed cells (non-green) displaying a silent X chromosome (red nuclear body) is shown in the bottom right-hand corner.


Expression of a pluripotency reporter,

Dr Josè Silva

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