Nuclear reprogramming of tissue cells back to an embryonic cell state is generally inefficient
Histone variant macroH2A marks embryonic differentiation in vivo and acts as an epigenetic barrier to induced pluripotency.
Nuclear reprogramming of tissue cells back to an embryonic cell state is generally inefficient. This reflects the stability of tissue cells. A long lasting question in biology concerns what particular mechanisms acquired during embryonic development are responsible for this stability. Our study identifies for the first time a link between a mechanism, macroH2A, and embryonic development, which antagonises reprogramming to an embryonic cell state.
Authors: Vincent Pasque, Aliaksandra Radzisheuskaya, Astrid Gillich, Richard P. Halley-Stott, Maryna Panamarova, Magdalena Zernicka-Goetz, M. Azim Surani, José C.R. Silva
Publication details: http://jcs.biologists.org/content/early/2012/10/12/jcs.113019.full.pdf+html