Exit From Pluripotency
Exit From Pluripotency Is Gated By Intracellular Redistribution Of The Bhlh Transcription Factor Tfe3.
Embryonic stem cells (ESCs) have the ability to develop into any tissue or organ. To do this they must first lose their stem cell identity which in turn allows formation of specific cell types, such as nerve or muscle. Understanding how ESCs change their identity is a fundamental challenge that can improve our ability to use stem cells in medical application. Joerg Betschinger tested thousands of genes to identify those that control the loss of ESC identity. He found a new mechanism involving genes called Folliculin and Tfe3 that were not previously known to act in ESCs. Intriguingly, these genes cause kidney cancer in humans, pointing to a link between stem cells and tumour formation.
Authors: Joerg Betschinger, Jennifer Nichols, Sabine Dietmann, Philip D. Corrin, Patrick J. Paddison, Austin Smith