Functional nerve cells from skin cells

SCI researchers have contributed to a study describing a new method of generating mature nerve cells from skin cells could greatly enhance understanding of neurodegenerative diseases, and could accelerate the development of new drugs and stem cell-based regenerative medicine.

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Full article in Development.

Publication details:

Ali FR, Cheng K, Kirwan P, Metcalfe S, Livesey FJ, Barker RA, Philpott A. The phosphorylation status of Ascl1 is a key determinant of neuronal differentiation and maturation in vivo and in vitro. Development. PMID: 24821983

Functional nerve cells

Mature nerve cells generated from human cells using enhanced transcription factors

Image credit: Fahad Ali

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