A competitive protein interaction network buffers Oct4-mediated differentiation
A competitive protein interaction network buffers Oct4-mediated differentiation to promote pluripotency in embryonic stem cells
This work shows that pluripotency requires a strict ratio of Nanog and Oct4 and that this is achieved by the dynamics of a competitive network of protein complexes with β-catenin at the centre. This mechanism provides an explanation for the recent results from J. Silva that cells with low levels of Oct4 are trapped in the pluripotent state (Radzisheuskaya, A. et al. 2013 A defined Oct4 level governs cell state transitions of pluripotency entry and differentiation into all embryonic lineages. Nature Cell Biology 15, 579-590). The results provide a new dimension of pluripotency and put a spotlight on protein interaction networks play in ES cells.
Journal: Molecular Systems Biology
Authors: Silvia Muñoz Descalzo, Pau Rué, Fernando Faunes, Penelope Hayward, Lars Martin Jakt, Tina Balayo, Jordi Garcia-Ojalvo & Alfonso Martinez Arias