The NuRD complex regulates neural cell fate determination and differentiation in the cerebral cortex
Chromatin modifying complexes have key roles in regulating various aspects of neural stem cell biology, including self-renewal and neurogenesis. Our data suggest that one such chromatin modifying complex, NuRD, is required to repress inappropriate transcription in both progenitor cells and neurons to facilitate appropriate cell lineage choice and differentiation programmes.
Collaboration between Hendrich and Livesey labs:
Knock E, Pereira J, Lombard PD, Dimond A, Leaford D, Livesey FJ, Hendrich B. The Methyl Binding Domain 3/nucleosome Remodeling and Deacetylase Complex Regulates Neural Cell Fate Determination and Terminal Differentiation in the Cerebral Cortex. Neural Development. PMID: 25934499