The NuRD complex regulates neural cell fate determination and differentiation in the cerebral cortex

Chromatin modifying complexes have key roles in regulating various aspects of neural stem cell biology, including self-renewal and neurogenesis. Our data suggest that one such chromatin modifying complex, NuRD, is required to repress inappropriate transcription in both progenitor cells and neurons to facilitate appropriate cell lineage choice and differentiation programmes.


Publication details:

Collaboration between Hendrich and Livesey labs:
Knock E, Pereira J, Lombard PD, Dimond A, Leaford D, Livesey FJ, Hendrich B. The Methyl Binding Domain 3/nucleosome Remodeling and Deacetylase Complex Regulates Neural Cell Fate Determination and Terminal Differentiation in the Cerebral Cortex. Neural Development. PMID: 25934499

mouse cortex

Image shows a slice through the cortex of mouse embryos, with different kinds of neurons labelled red, green or blue. In normal development each neuronal subtype is located in a distinct region, giving rise to the appearance of stripes of colour. Embryos lacking a component of the NuRD chromatin remodelling complex lose this spatial distinction, and different neuronal subtypes are located in the same regions of the cortex.

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