NANOG amplifies STAT3 activation and they synergistically induce the naïve pluripotent program
Naïve pluripotent stem cells have the ability to differentiate into any cell of an adult organism, and thus hold great promise for drug development and regenerative medicine. Such cells can be obtained directly from the embryo, or by reprogramming of a differentiated cell back to a naïve pluripotent identity. In this study, we connect NANOG with STAT3 signalling, two key mechanisms driving naïve pluripotency acquisition. Our finding that NANOG modulates signal transduction of extracellular cues adds a new dimension to the interplay between external environment and nuclear control networks to instate and reinforce cellular identity.
Stuart HT, van Oosten AL, Radzisheuskaya A, Martello G, Miller A, Dietmann S, Nichols J, Silva JC. NANOG Amplifies STAT3 Activation and They Synergistically Induce the Naive Pluripotent Program. Current Biology. PMID: 24462001
Full article in Current Biology