Deterministic progenitor behavior and unitary neuron production in the neocortex

Radial glial progenitors (RGPs) are responsible for generating neurons and glia in the mammalian neocortex. However, the kinetics and division pattern of RGPs remains largely unknown. We show that RGPs progress through a remarkably orderly deterministic program of proliferation, neurogenesis and gliogenesis. During the neurogenic phase, individual RGPs produce a unitary output of around 8-9 neurons located in both superficial and deep layers, suggesting a quantal nature of neuronal production in neocortical histogenesis.

Full article in Cell

Publication details: Gao P, Postiglione MP, Krieger TG, Hernandez L, Wang C, Han Z, Streicher C, Papusheva E, Insolera R, Chugh K, Kodish O, Huang K, Simons BD, Luo L, Hippenmeyer S, Shi S-H. Deterministic progenitor behavior and unitary neuron production in the neocortex. Cell. Volume 159, Issue 4, p775–788, 6 November 2014.

Clonal expansion of genetically labelled cells in the cortex.

Clonal expansion of genetically labelled cells in the cortex.

Image credit: Peng Gao

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