SCI scientists reset human stem cells to earliest developmental state
SCI researchers have managed to induce a ground state by rewiring the genetic circuitry in human embryonic and induced pluripotent stem cells. Their “reset” cells share many of the characteristics of authentic naïve embryonic stem cells isolated from mice, suggesting that they represent the earliest stage of development.
The study, published in Cell, will lead to a better understanding of human development and could in future allow the production of safe and more reproducible starting materials for a wide range of applications including cell therapies.
Read more: http://www.mrc.ac.uk/news-events/news/scientists-reset-human-stem-cells-to-earliest-developmental-state/ and http://www.cam.ac.uk/research/news/scientists-reset-human-stem-cells-to-earliest-developmental-state
Read the published article in Cell
Publication details: Takashima Y, Guo G, Loos R, Nichols J, Ficz G, Krueger F, Oxley D, Santos F, Clarke J, Mansfield W, Reik W, Bertone P, Smith A. Resetting transcription factor controle circuitry towards ground state pluripotency in human. Cell Volume 158, Issue 6, p1254–69, 11 September 2014.