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Human Stem Cells for Craniomaxillofacial Reconstruction

Human stem cell research represents an exceptional opportunity for regenerative medicine and the surgical reconstruction of the craniomaxillofacial complex. The in vitro production of fully functional cells for skin, muscle, cartilage, bone and neurovascular tissue formation from human stem cells, may one day provide novel materials for the reconstructive surgeon operating on patients with both hard and soft tissue deficit due to cancer, congenital disease or trauma. Here we provide an overview of human stem cells in disease modelling, drug screening and therapeutics, whilst also discussing the application of regenerative medicine for craniomaxillofacial tissue deficit and surgical reconstruction.

Publication Details:

Jalali M, Kirkpatrick NA, Cameron MG, Pauklin S, Vallier L. Human Stem Cells for Craniomaxillofacial Reconstruction. Stem Cells and Development. PMID: 24564584

Full article in Stem Cells and Development


Application of patient-specific induced pluripotent stem cells for craniofacial reconstruction. Induced pluripotent stem cells can be differentiated into all cell types necessary for reconstructing the craniomaxillofacial complex

Image credit: Morteza Jalali

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