Defining an essential transcription factor program for naïve pluripotency
Prof Austin Smith and investigators from the Microsoft Research Computational Science Laboratory, also in the UK, developed a powerful new computational modelling method that predicts embryonic stem cell self-renewal versus differentiation. This enabled the authors to identify the essential “biological program” governing pluripotency. The successful conjunction of computation and experimentation marks a significant milestone in biological science.
Full article in Science.
Dunn SJ, Martello G, Yordanov B, Emmott S, Smith AG. Defining an essential transcription factor program for naïve pluripotency. Science. PMID: 24904165