Defining an essential transcription factor program for naïve pluripotency

Prof Austin Smith and investigators from the Microsoft Research Computational Science Laboratory, also in the UK, developed a powerful new computational modelling method that predicts embryonic stem cell self-renewal versus differentiation. This enabled the authors to identify the essential “biological program” governing pluripotency. The successful conjunction of computation and experimentation marks a significant milestone in biological science.

Full article in Science.

Publication details

Dunn SJ, Martello G, Yordanov B, Emmott S, Smith AG. Defining an essential transcription factor program for naïve pluripotency. Science. PMID: 24904165

Read more: http://www.the-scientist.com/?articles.view/articleNo/40151/title/Minimal-Toolkit-for-Stem-Cell-Self-Renewal/

Science Journal

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