First randomised controlled trial to show spinal cord regeneration in dogs

Specialised cells of the olfactory system called olfactory ensheathing cells (OECs) are able to support recovery following experimental spinal cord injury in laboratory animals. However, it is not known whether this promising experimental approach will work in clinical spinal cord injury. In this study paralysed domestic dogs with clinical (ie non-experimental) spinal cord injury were transplanted with their own OECs which resulted in a remarkable and significant improvement in their ability to move compared to non-transplanted controls. This study proves that OEC transplantation will be of benefit in humans with spinal cord injury.

Authors: Granger N, Blamires H, Franklin R, Jeffery ND

Publication details: Brain

For more information visit the University of Cambridge and the Medical Research Council.

This project has now finished and no follow-on study is planned.

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Autologous olfactory mucosal cell transplants in clinical spinal cord injury: a randomized, double-blinded trial in a canine translational model

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