BET inhibitor resistance emerges from leukaemia stem cells

Targeting the bromodomains of BET family proteins has emerged as one of the most promising epigenetic therapies in a variety of cancers. In this report, which started in the Huntly lab, Chun et al. report mechanisms of drug resistance to these inhibitors. This information can be utilised in the clinic, allowing combination treatment strategies in order to improve clinical outcomes. Read more in Nature.

Mechanisms of IBET resistance

Mechanisms of IBET resistance (CY Fong et al. Nature 000, 1-5 (2015) doi:10.1038/nature14888)

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