Dr Simon Buczacki
Cellular quiescence in intestinal homeostasis and tumorigenesis
Departmental Affiliation: Cambridge Cancer Centre
My scientific and clinical interests lie within translational surgical oncology. In particular I have specialised interests in the fields of intestinal stem and cancer stem cell biology. My research philosophy centres around the tenet of applying an understanding of normal cellular behaviour to that of oncogenically transformed populations. It therefore follows that my research encompasses the study of normal intestinal stem cell biology using contemporary tools such as GEMMs, lineage tracing and organoid assays in combination with the use of NGS and xenotransplantation to help understanf clonogenic cancer cell behaviour. I have a particular interest related to cellular quiescence and have developed robust tools to understand and manipulate their behaviour to clinical advantage.
Quiescent tumour cells (highlighted) in an intestinal tumour organoid. Image credit: Simon Buczacki
CRUK Clinician Scientist and Honorary Consultant Colorectal Surgeon