Dr Cristina Pina
Haematopoietic stem cells
Departmental Affiliation: Department of Haematology
Haematopoietic stem cells balance molecular programmes of self-renewal and differentiation in order to sustain mature blood cell production and maintain a pool of undifferentiated multipotent cells throughout the lifetime of the individuals. Corruption of some of these programmes in favour of self-renewal and/or blocking differentiation may result in malignant transformation to generate leukaemia. Additionally, stem cells have the capacity to respond to increased demands in production of mature lineages, e.g. upon injury.