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Wellcome Trust - Medical Research Council

Cambridge Stem Cell Institute

Studying at Cambridge

 

Dr Cristina Pina

Cristina Pina 2017Dr Cristina Pina

Transcriptional heterogeneity in normal and malignant stem cell fate decisions

Departmental Affiliation: Department of Haematology

 

 

Research

Haematopoietic stem cells balance molecular programmes of self-renewal and differentiation in order to sustain mature blood cell production and maintain a pool of undifferentiated multipotent cells throughout the lifetime of the individuals. Corruption of some of these programmes in favour of self-renewal and/or blocking differentiation may result in malignant transformation to generate leukaemia. Additionally, stem cells have the capacity to respond to increased demands in production of mature lineages, e.g. upon injury.

 

Pina research HQ 2017

Association between cell fate transitions and transcriptional noise; potential for therapeutic intervention in acute myeloid leukaemia. Image credit: Cristina Pina

External links

www.haem.cam.ac.uk/staff/senior-staff/dr-cristina-pina/

 

CSCI collaborators

Brian Huntly 

Alfonso Martinez-Arias 

George Vassiliou