Professor Christine Watson
Stem cell and lineage determining factors in mammary gland
Laboratory Location: Cambridge Cancer Centre
Departmental Affiliation: Department of Pathology
We are interested in identifying transcriptional regulators that control lineage commitment of mammary stem cells. We have identified a novel gene, Zfp157, that is a master regulator of the alveolar lineage. Further work is focussed on lineage tracing using fluorescent fusion proteins and H2B-GFP to isolate and characterise long label-retaining cells.