Professor Andrew McCaskie
Regenerative therapies for bone and cartilage repair
Laboratory: Addenbrooke's Hospital, Cambridge Biomedical Campus. Departmental Affiliation: Surgery, Division of Trauma and Orthopaedic Surgery
Professor McCaskie is the Professor of Orthopaedic Surgery at the University of Cambridge. He is an orthopaedic surgeon with an interest in lower limb surgery e.g. hip arthroscopy and an interest in regenerative research.
He is the Director of the Arthritis Research UK Tissue Engineering Centre. The £6 million Centre is based at four sites: Newcastle University, the University of Aberdeen, Keele University/the Robert Jones and Agnes Hunt Hospital NHS Foundation Trust in Oswestry and the University of York. Funded by a core grant of £2.4 million over five years from Arthritis Research UK with a further £3.4 million pledged by the four participating universities, the centre brings together leading clinicians, engineers and biologists from research and clinical groups.
The aim and potential clinical impact is to treat early osteoarthritis by introducing stem cells into damaged joints in conjunction with exisiting surgical procedures. Prof McCaskie leads the Smart Step consortium (£1.1M) as part of Stage II UK Regenerative Medicine Platform. The aim is to develop cell-free approaches to Osteoarthritis and establish a translational pipeline for their development. He also facilitates Clinical Engagement as part of the Centre for Innovative Manufacturing in Medical Devices (MeDe) led by Leeds University.
Professor McCaskie's aim is to develop innovative solutions for patient benefit, particularly in Osteoarthritis (OA), which affects around 8 million people in the UK alone. He is currently developing translational pathways for regenerative therapy in this area. This seeks to use stratified and experimental medicine approaches, particularly focused on imaging and tissue analysis during cartilage repair surgery. The latter will include cell characterisation by phenotype and single cell analysis.
- Haddad FS, McCaskie AW. From needle to knife. Bone Joint J 2015, 97-B(1):1-2. PMID:25568405
- Evangelou E, Kerkhof HJ, McCaskie A, Valdes AM. A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip. Ann Rheum Dis. 2014;73:2130-2136 PMCID:PMC4251181
- Rodriguez-Fontenla C, Calaza M, Evangelou E, Valdes AM, McCaskie A, Zeggini E, Spector TD, Gonzalez A. Assessment of osteoarthritis candidate genes in a meta-analysis of 9 genome-wide association studies. Arthritis Rheum. 2014 Apr;66(4):940-9 PMCID:PMC4660891
- Elliott KS, Chapman K, Day-Williams A, McCaskie A, The arcOGEN consortium, Zeggini E. Evaluation of the genetic overlap between osteoarthritis with body mass index and height using genome-wide association scan data. Ann Rheum Dis. 2013, 72(6), 935-941. PMCID:PMC3664369
- Stoddard JE, Deehan DJ, Bull AMJ, McCaskie AW, Amis AA. The kinematics and stability of single-radius versus multi-radius femoral components related to Mid-range instability after TKA. Journal of Orthopaedic Research 2013, 31(1), 53-58. PMID:22696446
- Hudson G, Panoutsopoulou K, McCaskie A, Loughlin J, Chinnery PF; arcOGEN Consortium. No evidence of anassociation between mitochondrial DNA variants and osteoarthritis in 7393 cases and 5122 controls. Ann Rheum Dis. 2013 Jan;72(1):136-9. PMCID:PMC3551219
- Zeggini E, Panoutsopoulou K, Southam L, McCaskie A, Valdes AM, Spector TD, Loughlin J. Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Lancet 2012, 380(9844), 815-823. PMCID:PMC3443899
- Day-Williams AG, Southam L, Panoutsopoulou K, McCaskie A, Zeggini E. A variant in MCF2L is associated with osteoarthritis. American Journal of Human Genetics 2011, 89(3), 446-450. PMCID:PMC3169824
- Musila N, Underwood M, McCaskie AW, Black N, Clarke A, van der Meulen JH. Referral recommendations for osteoarthritis of the knee incorporating patients' preferences. Family practice. 2011;28(1):68-74. PMCID:PMC3023074
- Mitchell EA, Chaffey BT, McCaskie AW, Lakey JH, Birch MA. Controlled spatial and conformational display of immobilised bone morphogenetic protein-2 and osteopontin signalling motifs regulates osteoblast adhesion and differentiation in vitro. BMC Biology 2010, 8: 57 PMCID:PMC2880964