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Professor Andrew McCaskie

McCaskie Andrew 128Professor Andrew McCaskie

Regenerative therapies for bone and cartilage repair


Laboratory: Addenbrooke's Hospital, Cambridge Biomedical Campus. Departmental Affiliation: Surgery, Division of Trauma and Orthopaedic Surgery 



Professor McCaskie is the Professor of Orthopaedic Surgery at the University of Cambridge. He is an orthopaedic surgeon with an interest in lower limb surgery e.g. hip arthroscopy and an interest in regenerative research. 

He is the Director of the Arthritis Research UK Tissue Engineering Centre. The £6 million Centre is based at four sites: Newcastle University, the University of Aberdeen, Keele University/the Robert Jones and Agnes Hunt Hospital NHS Foundation Trust in Oswestry and the University of York. Funded by a core grant of £2.4 million over five years from Arthritis Research UK with a further £3.4 million pledged by the four participating universities, the centre brings together leading clinicians, engineers and biologists from research and clinical groups.

The aim and potential clinical impact is to treat early osteoarthritis by introducing stem cells into damaged joints in conjunction with exisiting surgical procedures. Prof McCaskie leads the Smart Step consortium (£1.1M) as part of Stage II UK Regenerative Medicine Platform. The aim is to develop cell-free approaches to Osteoarthritis and establish a translational pipeline for their development. He also facilitates Clinical Engagement as part of the Centre for Innovative Manufacturing in Medical Devices (MeDe) led by Leeds University. 



Professor McCaskie's aim is to develop innovative solutions for patient benefit, particularly in Osteoarthritis (OA), which affects around 8 million people in the UK alone. He is currently developing translational pathways for regenerative therapy in this area. This seeks to use stratified and experimental medicine approaches, particularly focused on imaging and tissue analysis during cartilage repair surgery. The latter will include cell characterisation by phenotype and single cell analysis. 


Key Publications