Professor Andrew McCaskie
Regenerative therapies for bone and cartilage repair
Laboratory: Addenbrooke's Hospital, Cambridge Biomedical Campus.
Departmental Affiliation: Surgery, Division of Trauma and Orthopaedic Surgery
Professor McCaskie is the Professor of Orthopaedic Surgery and Head of the Department of Surgery at the University of Cambridge. He is the Director of the Arthritis Research UK Tissue Engineering Centre, which brings together many centres; University of Cambridge, Newcastle University, the University of Aberdeen, Keele University/the Robert Jones and Agnes Hunt Hospital NHS Foundation Trust in Oswestry and the University of York. Funded by a core grant of £2.4 million over the first five years from Arthritis Research UK, the Centre grant was recently renewed (£1.9M) until 2021. The centre brings together leading clinicians, engineers and biologists from research and clinical groups and to develop regenerative therapies for people with Osteoarthritis.
Professor McCaskie leads the Smart Step programme (£1.1M) as part of Stage II UK Regenerative Medicine Platform. The programme aims to develop cell-free approaches to Osteoarthritis and establish a translational pipeline for their development. He also facilitates clinical engagement as part of the Centre for Innovative Manufacturing in Medical Devices (MeDe) led by Leeds University.
Arthritis Research UK, MRC, Evelyn Trust, UK Regenerative Medicine Platform
Immunofluorescence image of a section through a joint illustrating the cellularity (nuclei stained blue) of the articular cartilage and meniscus. The boundaries of the two apposing articular cartilage surfaces and the meniscal tissue are marked with yellow lines.
Professor McCaskie's aim is to develop innovative therapies for musculoskeletal disease, particularly in Osteoarthritis (OA) which affects around 8 million people in the UK alone. He is currently developing translational pathways for regenerative therapy in this area, linking laboratory research with clinical treatment, including clinical trials.
Laboratory research programmes focus on the opportunity to use adult stem/stromal populations, along with other relevant cell types (haematopoietic and chondrocyte) either alone or with tissue engineering approaches to target early disease. Research also considers the mechanisms of joint destruction relevant to repair.
Translational and clinical programmes seek to use stratified and experimental medicine approaches, particularly focused on imaging and tissue analysis during cartilage repair surgery. The latter will include cell characterisation by phenotype and single cell analysis to understand the role played by cell therapies in the repair of joint tissues.
Anna Albiero, Francesca Emily, Beaton, Mark Birch, Karim Fekir, Sophie Frankham-Wells, Frances Henson, Wasim Khan, Helen Lydon, Stephen McDonnell, Karin Newell, Virginia Piombo
- Haddad FS, McCaskie AW. From needle to knife. Bone Joint J 2015, 97-B(1):1-2. PMID:25568405
- Evangelou E, Kerkhof HJ,... McCaskie A,... Valdes AM. A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip. Ann Rheum Dis. 2014;73:2130-2136 PMCID:PMC4251181
- Rodriguez-Fontenla C, Calaza M, Evangelou E, Valdes AM,... McCaskie A,... Zeggini E, Spector TD, Gonzalez A. Assessment of osteoarthritis candidate genes in a meta-analysis of 9 genome-wide association studies. Arthritis Rheum. 2014 Apr;66(4):940-9 PMCID:PMC4660891
- Elliott KS, Chapman K, Day-Williams A,... McCaskie A,... The arcOGEN consortium,... Zeggini E. Evaluation of the genetic overlap between osteoarthritis with body mass index and height using genome-wide association scan data. Ann Rheum Dis. 2013, 72(6), 935-941. PMCID:PMC3664369
- Zeggini E, Panoutsopoulou K, Southam L,... McCaskie A, Valdes AM, Spector TD, Loughlin J. Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Lancet 2012, 380(9844), 815-823. PMCID:PMC3443899