Professor Christine Watson
Stem cell and lineage determining factors in mammary gland
Cambridge Cancer Centre
Department of Pathology
We are interested in identifying transcriptional regulators that control lineage commitment of mammary stem cells. We have identified a novel gene, Zfp157, that is a master regulator of the alveolar lineage. Further work is focussed on lineage tracing using fluorescent fusion proteins and H2B-GFP to isolate and characterise long label-retaining cells.