Dr Doug Winton
Intestinal stem cells
Cancer Research UK Cambridge Research Institute (CR-UK CRI)
Renewing tissues and many cancers are maintained by a small number of long-lived stem cells. Most models of stem cell organisation take account of their longevity and assume that they are stable populations carrying unique identifying characteristics.
However, this interpretation now seems too simplistic. For example the cell surface signatures of stem cells may not be as stable over time as previously thought.
Our approach is pragmatic: to identify novel ways of assaying stem cells in situ with respect to the functional end-points that are integral to their biology.