Dr Brian Hendrich
Transcriptional Control of Stem Cell Fate
Department of Biochemistry, University of Cambridge
Brian grew up near Seattle, Washington, and consequently is a consummate coffee snob.
He got his PhD from Stanford University in 1995 working on X chromosome inactivation with Huntington Willard. In 1995 he joined the lab of Adrian Bird at the University of Edinburgh and participated in the discovery and characterisation of a family of methyl-CpG binding proteins in mammals.
In 2001 he obtained a Wellcome Trust Career Development Fellowship to start his own laboratory at the Institute for Stem Cell Research, University of Edinburgh. In 2008 he moved to the Wellcome Trust Centre for Stem Cell Research in Cambridge.
He is currently a Wellcome Trust Senior Research Fellow in the Basic Biomedical Sciences, and Director of the PhD Programme in Stem Cell Biology for the Cambridge Stem Cell Institute.
Cells of early mammalian embryos have the potential to develop into any adult cell type, and are thus said to be pluripotent. Pluripotency is lost during embryogenesis as cells begin to commit to specific developmental pathways.
The goal of the group is to understand the transcriptional regulatory mechanisms that underpin the ability of a homogeneous population of pluripotent cells to give rise to the massive heterogeneity existing in somatic tissues. To achieve this they are using a combination of biochemistry, genetics, developmental biology, bioinformatics, ES cell manipulation, in vitro differentiation, proteomics, and gene expression analyses.
We are part of the EU FP7 Project "4DCellFate"
We are part of the Marie Cuire Initial Training Network "DisChrom"
PHOTO CREDIT ANZY MILLER AND HER CRONIES!
Keisuke Kaji 2002-2007 Currently: ESF Research Fellow, University of Edinburgh
Patrick McDonel 2007-2011 Currently: Postdoctoral Researcher, The Whitehead Institute, MIT
Dziugas Gineitis 2007-2009 Currently: Research Scientist (Industry, UK)
Paulina Latos 2008-2011 Currently: Postdoctoral Researcher, The Babraham Institute
Erin Knock 2009-2012 Currently: Postdoctoral Researcher, University of Toronto
. Aoife O'Shaughnessy, BBSRC Case Studentship with Pfizer PLC, University of Cambridge, PhD Awarded 2012. Currently: Postdoctoral Research Fellow, University of Cambridge
. Ita Costello, Wellcome Trust Four Year PhD Student, University of Edinburgh, PhD Awarded 2008. Currently: Postdoctoral Research Fellow, University of Oxford
. Christine Powell (Heliwell), MRC PhD Studentship, University of Edinburgh, PhD Awarded 2007. Currently: General Adventurer and Businesswoman....
. Isabel Martin Caballero, School of Biological Sciences PhD Studentship, University of Edinburgh, PhD Awarded 2006. Currently: Postdoctoral Fellow, Karolinska Instituet
. Lars Hansen, Masters Student from Raboud University Nijmegen, 2011-2012. Currently: PhD student, Oxford University
. Philip Brennecke, Erasmus visiting Masters Student from Freie Universität, Berlin. 2008-2009. Currently: PhD student, EMBL, Germany.
. Manoe Janssen, Erasmus visiting Masters Student from Raboud University Nijmegen, 2008. Currently: Postdoctoral Fellow K.U. Leuven, Belgium
Plain EnglishEmbryonic stem cells can either make more copies of themselves, or differentiate to form any cell type in the body. How cells make the decision to differentiate, and which cell type to differentiate into, is controlled by gene expression patterns. We are studying how precise control of gene expression allows cells to make these decisions.
O’Shaughnessy, A. and Hendrich, B. (2013) CHD4 in the DNA-damage response and cell-cycle progression: not so NuRDY now. Biochem. Soc. Trans. 41(3):777-782. doi:10.1042/BST20130027.
- Reynolds, N., O’Shaughnessy, A. and Hendrich, B. (2013) "Transcriptional repressors: multifaceted regulators of gene expression" Development, 140(3), 505–512. doi:10.1242/dev.083105
- Reynolds, N., Latos, P., Hynes-Allen, A., Loos, R., Leaford, D., O’Shaughnessy, A., Mosaku, O., Signolet, J., Brennecke, P., Kalkan, T., Costello, I., Humphreys, P., Mansfield, W., Nakagawa, K., Strouboulis, J., Behrens, A. Bertone, P., and Hendrich, B. (2012) “NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment” Cell Stem Cell 10(5): 583-594. 10.1016/j.stem.2012.02.020; Open Access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402183/
Latos, P.A., Helliwell, C., Mosaku, O., Dudzinska, D.A., Stubbs, B.,Berdasco, M., Esteller, M., Hendrich, B. (2012) NuRD-dependent DNA methylation prevents ES cells from accessing a trophectoderm fate. Biology Open
McDonel, P., Demmers, J., Tan, D.M.W., Watt, F., and Hendrich, B. (2012) “Sin3a is essential for the genome integrity and viability of pluripotent cells.” Developmental Biology 363:62, doi:10.1016/j.ydbio.2011.12.019
- Reynolds, N., Salmon-Divon, M., Dvinge, H., Balasooriya, G., Leaford, D., Hynes-Allen, A., Behrens, A., Bertone, P. and Hendrich, B. (2012) “NuRD-mediated deacetylation of H3K27 facilitates recruitment of Polycomb Repressive Complex 2 to direct gene repression” EMBO Journal 31:593, doi:10.1038/emboj.2011.431