Other PhD opportunities
The following PhD studentships are now available:
Impact of Cell & Gene Therapy on the Function and Molecular Regulation of Haematopoietic Stem Cells
Applications are invited for a 4-year Medical Research Council Industry CASE PhD studentship, which will be jointly supervised by Dr. Laurenti at the University of Cambridge and Dr. Francis at GlaxoSmithKline (GSK), to commence in October 2017.
The Laurenti laboratory combines state-of-the-art experimental and computational methods to study the unique biological and molecular properties of human haematopoietic stem cells (HSCs). GSK is a world leading research-based pharmaceutical company. In May 2015, the first autologous ex vivo gene therapy product, developed by the Cell and Gene Therapy (CGT) platform, was recently approved by the European Medicines Agency. CGT supports numerous cell and gene therapy projects from early phase to commerical launch, and the development of innovative technologies to enable improvements to cell and gene therapy manufacture.
The principal research aim of this project is to determine to what extent the gene therapy protocol affects the biology of HSCs. The project will combine single cell transcriptomics, lentiviral transduction technology, flow cytometry and single cell functional assays in vitro and in vivo. Adult HSCs and progenitor cells will be subjected to the gene therapy protocol and changes in their fate choices and transcriptome will be determined by single cell functional assays and single cell RNA-seq. This information will provide insights into how changes in the molecular circuitry of HSC alter their function under stress conditions, and will be used to guide process improvements to increase HSC functionality after transduction.
The primary research will be carried out mostly in Dr Laurenti’s laboratory but the student will spend a minimum of 6 months at GSK during the time of the fellowship.
We encourage applications from students with mathematical and/or bioinformatics skills.
- Applicants should hold or be about to achieve a First or Upper-Second (2.1) class degree in a relevant subject. Students with a Bachelor-level degree are encouraged to apply.
- MRC studentships are available to UK nationals and EU students who meet the UK residency requirements. More information is available at: http://www.mrc.ac.uk/skills-careers/studentships/studentship-guidance/student-eligibility-requirements/
How to Apply
- Complete our departmental Application Form*, which will include providing the details of two referees
- Submit your application documents which should include your Application Form, CV, and your Degree transcripts, in pdf format to: email@example.com
- Please ask your referees to submit references directly to the SCI Graduate Administrator by the application deadline: firstname.lastname@example.org, using "MRC iCASE 4-Year PhD studentship (Laurenti)" in the subject header. It is your responsibility for ensuring that both references are received by the closing date.
Application Deadline: Tuesday 14th February 2017 and shortlisted candidates will be interviewed between 27th-28th February 2017.
Informal Academic Enquiries to: Dr Elisa Laurenti email@example.com
Application Process Enquiries to: Graduate Administrator firstname.lastname@example.org.
For further details about our group and the institute, please visit:
- Laurenti lab: http://www.stemcells.cam.ac.uk/researchers/principal-investigators/elisa-laurenti
- Stem Cell Institute Research: http://www.stemcells.cam.ac.uk/researchers/
*Please note that for this project you DO NOT APPLY DIRECTLY TO THE MRC, but apply through the process above here at the Stem Cell Institute*.
Decoding the network logic for resetting pluripotency
The Smith Group at the Medical Research Council-Wellcome Trust Stem Cell Institute in Cambridge in partnership with the Computational Biology Group at Microsoft Research offers an exciting interdisciplinary 4-year PhD studentship commencing October 2017.
The pluripotent ground state of embryonic stem cells (ESCs) is governed by a self-reinforcing interaction network of transcription factors (Dunn et al, Science 2014). Combinations of factors within this network can induce somatic cells to acquire pluripotency, a process called molecular reprogramming (Takahashi and Yamanaka, Cell, 2006). Experimental and computational efforts have led to circuitry mapping of the key players in maintenance of the ESC state. However, how this molecular circuitry is launched and fully connected during reprogramming remains unclear. This project is a cross-disciplinary investigation to address systematically how cells transit to the pluripotent ESC state at the molecular network level. The multi-step, heterogeneous and asynchronous nature of the reprogramming process presents technical challenges. This project is designed to overcome these challenges by using a minimal reprogramming system and integrating quantitative single-cell gene expression profiling at defined reprogramming stages with computational network synthesis and modelling. This approach will transform a temporal series of single-cell snapshots of network status into reconfiguring network trajectories. Predictions formulated from the synthesised trajectores will be tested experimentally and the results used for iterative refinement of the model set.
As part of the BBSRC doctoral training programme, this 4-year PhD contains tailored training courses in the first six months of the studentship. In addition, a key element of this project is that the student will spend three months at Microsoft Research Cambridge, under the supervision of our collaborator, Dr Sara-Jane Dunn, to develop wider training and skills.
UK and EEA students who have, or are expecting to attain, at least an upper second class honours degree (or equivalent) in relevant biological subjects are invited to apply. The interdisciplinary nature of the project means that we welcome applications from students with mathematical and computing experience who are interested in using their skills to address stem cell biology questions.
How to Apply
- Please complete our departmental Application Form process here*, which will include submitting your CV, providing the details of two referees, and your Degree transcripts.
- Please ask your referees to submit references directly to the SCI Graduate Administrator: email@example.com, using "BBSRCiCASE student reference" in the subject headder.
Application Deadline: Friday 20th January 2017 and shortlisted candidates will be interviewed at the beginning of February.
Academic Enquiries to: Dr. Amy Li firstname.lastname@example.org.
Application Process Enquiries: Graduate Administrator email@example.com.
For further details about our group and the institute, please visit: http://www.stemcells.cam.ac.uk/researchers/principal-investigators/pressor-austin-smith http://www.stemcells.cam.ac.uk/
*Please note that for this project you DO NOT APPLY DIRECTLY TO BBSRC, but apply to Prof Smith here at the Stem Cell Institute, as above*
The following studentship deadlines have now closed...
University of Cambridge MRC are offering several fully funded PhD studentships for projects commencing in October 2017.
Students can apply for studentships with SCI members, details of which can be found below and here: http://mrcdtp.medschl.cam.ac.uk/prospective-students/how-to-apply/available-projects-for-2017/. The studentships provide an annual stipend of £17k for 3.5 years, full fees and research costs. The duration of the studentship allows for a funded period of write-up prior to thesis submission. In addition to excellent research facilities, students will have access to a wide variety of training and researcher development activities, many of which are offered through the Graduate School of Life Sciences and the wider University.
The closing date for applications is 1st December 2016. Interviews will be held late January 2017.
- Academic requirements: At least a 2:1 Honours degree from a UK university or equivalent.
- English language requirements: The University requires a high level of proficiency in English. For details, click here http://www.graduate.study.cam.ac.uk/international-students/competence-english/will-i-have-language-requirement
- Nationality: Eligibility for the studentships is subject to MRC nationality and residence criteria. Click here for details
How to Apply
- Applicants are encouraged to contact prospective supervisors for further information about specific projects before applying.
- Applications must be made on the University’s online portal. Click here for a link to the Graduate Admissions webpages (http://www.graduate.study.cam.ac.uk/how-do-i-apply).
- Please also follow the instructions on the Cambridge MRC DTP website: http://mrcdtp.medschl.cam.ac.uk/prospective-students/how-to-apply/ The course code is MDSM22. You can select up to two projects – please add these to the ‘Research title’ field in order of preference quoting the project ID. In the ‘Research summary’ field provide a brief synopsis of why you have chosen your project/s. Please provide the name of the Primary Supervisor for your first choice project in the ‘Research Supervisor’ field.
You need to upload the following documents with your application:
- Transcripts or degree certificates
- English language score report forms (if English is not your first language)
Note: The two referees you list on the application form will be contacted automatically for their references, so please ensure you provide their correct email addresses.
Application Deadline: 1st December 2016. Interviews will be held late January 2017.
General application enquiries: please email the Higher Degrees Office at firstname.lastname@example.org
Cambridge Cancer Centre supports a broad programme of formal education and training designed to nurture the next generation of cancer researchers and clinicians. They will fund up to 10 PhD studentships (including clinical and non-clinical students) for 2017 with projects covering an exciting range studies, including those with several SCI Principal Investigators, listed below.
Applications are invited from UK, EU and non-EU students from non-clinical or clinical disciplines.
Twenty projects are available to choose from, of which 10 may be funded, supporting the top 10 student applicants. Applicants can select up to two projects (a first and second choice) when applying. Each of the project titles below links to a pdf giving an outline of the project. For further information you are encouraged to study the website of the Lead Investigator, and Co-Investigators where applicable. Below are the Stem Cell Institue Principal Investigator projects available.
How to Apply
Apply directly to Cambridge Cancer Centre. For further information about the studentships, funding, and application process, please visit the Cambridge Cancer Centre website: http://www.cambridgecancercentre.org.uk/studentships
Application Deadline: For both non-clinical and clinical applicants the application deadline is 30 November 2016.