2010 - 2014
Dates of Study: Oct 2010 - Sep 2014
PhD Supervisor: Dr Juan-Jose Ventura
Studentship Sponsor: Herchel Smith
Thesis Title: Human lung bronchioalveolar stem cells in homeostasis and cancer
I have worked on understanding how lung stem cells renew and heal adult human lungs and how deviations of their tight control can lead to lung cancer.
- Oeztuerk-Winder F, Guinot A, Ochalek A and Ventura JJ. Regulation of human lung alveolar multipotent stem cells by a novel p38a MAPK/miR-17-92 axis. EMBO J. 2012.
- Guinot A, Oeztuerk-Winder F and Ventura JJ. MiR-17-92/p38a dysregulation enhances Wnt signal and selects Lgr6+ cancer stem cell-like cells during human lung adenocarcinoma progression. In preparation.
- Oeztuerk-Winder F, Lemke A, Fink J, Guinot A, Page M, Jensen K and Ventura JJ. Lrig1 marks a distinct population of early progenitors with potential to regenerate all bronchiolar cell types. Nature Cell Biology (in press).