Ana Leal Cervantes
2010 - 2014
Dates of Study: Oct 2010 - Jan 2015
Programme: Wellcome Trust 1+3 Programme in Stem Cell Biology
PhD Supervisor: Dr Bertie Göttgens
Studentship Sponsor: The Wellcome Trust
Thesis Title: Transcriptional Consequences of Jak-Stat signalling in Haematopoiesis.
Public Outreach: Ana was a volunteer on the Stem Cell Institute stand at the University of Cambridge annual Science Festival in 2012 & 2014, and contributed to the University's 'BluSci' magazine.
Ana is currently applying for PostDoc positions.
Cell fate choices are the result of interactions between external cues and the intracellular environment. Extracellular signals that regulate blood lineages include cytokines, some of which convey signals through the Jak/Stat pathway. As the specific mechanisms by which Stats regulate transcription are less well defined, my PhD project focused on understanding how cytokines alter gene expression (and thus cell phenotype) via the Jak/Stat pathway.
- Calero‐Nieto FJ et al. (2014). Key regulators control distinct transcriptional programs in blood progenitor and mast cells. The EMBO Journal. PMID: 24760698.
- Hyun Jung Park et al. Tyrosine-unphosphorylated STAT5 represses the megakaryocytic transcriptional program. (Manuscript under review, 2015).