2011 - 2015
The development of an embryo involves a series of spatio-temporally ordered cell fate assignations. These decisions are controlled by mechanical and chemical inputs and lead to the emergence of all tissues and organs in the body. I am interested in how cells make decisions about their fate during development. Particularly, my PhD research focused on how cells interpret various environmental signals and integrate them to make precise and reproducible decisions. I have used the specification of the respiratory lineage, which gives rise to lung and trachea, as a paradigm.
- Budjan C, Rawlins E, Martinez Arias A. Temporal Integration of Signals Confers Endodermal Progenitor Competence and Specifies the Respiratory Lineage. (In preparation).