2011 - 2015
Dates of Study: Jan 2011 - Jan 2015
PhD Supervisor: Dr Mark Kotter
Studentship Sponsor: PhD in Clinical Neuroscience, funded by Becas Chile: CONICYT Scholarship
Thesis Title: Promoting remyelination in the central nervous system by modulation of signaling cascades in oligodendrocyte precursor cells
Research Topic: My research focused on modulation of the signalling cascades in OPCs to promote differentiation and CNS remyelination. In particular, I'm studying the role of PKC alpha and oestrogen receptor signalling pathways by using pharmacological modulators and small interference RNA (siRNA) approach.
In March 2015, Ginez began his Postdoctoral Research Associate career in Professor Robin Franklin's lab (co-supervised by Dr. Chao Zhao) at the Stem Cell Institute - Clifford Allbutt Building, University of Cambridge.
Remyelination is a regenerative process characterised by the formation of new myelin sheaths on demyelinated axons. In the central nervous system (CNS) this process is triggered by a progenitor cell called the oligodendrocyte precursor cell (OPC). Remyelination occurs in two stages, firstly OPCs proliferate, migrate and engage demyelinated axons. Secondly, OPCs differentiate into myelin-forming oligodendrocytes. Under pathological conditions, like multiple sclerosis (MS), remyelination fails and, therefore, axons remain demyelinated and prone to injury. Clinical evidence has shown that differentiation rather than proliferation/migration is inhibited, therefore stimulating OPC differentiation constitutes a promising target for demyelinating diseases.
My research focuses on modulation of the signalling cascade in OPCs to promote differentiation and CNS remyelination. In particular, I'm studying the role of PKC alpha and oestrogen receptor signalling pathways by using pharmacological modulators and small interference RNA (siRNA) approach.
- Syed YA et al. (2013). Inhibition of phosphodiesterase‐4 promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination. EMBO Molecular Medicine, 5, 1918-1934. PMID:24293318.