2009 - 2013
Dates of Study: Oct 2009 - Sept 2013
PhD Supervisor: Dr Brian Hendrich
Studentship Sponsor: Medical Research Council
Thesis Title: Control of self-renewal and pluripotency by the Mbd3/NuRD complex
When he finished his PhD in October 2013, Jason worked as a Research Assistant and then as a PostDoc in Dr Brian Hendrich's group at the Stem Cell Institute, University of Cambridge.
In November 2014, Jason moved to Australia and from January 2016 has been working as a Consulting Data Scientist at 'Data to Decisions Collaborative Research Centre' in Adelaide, Australia.
I investigated the phenotype of Mbd3-deleted mouse embryonic stem cells. These cells have previously been shown to be resistant to differentiation in vitro and fail to form viable embryos in vivo. My data showed that, unlike wild type cells, these mutant cells do not follow an orderly differentiation trajectory. I have also identified a BMP signalling deficiency in these cells which may account for some of this behaviour.
- Reynolds N, Latos P, Hynes-Allen A, Loos R, Leaford D, O'Shaughnessy A, Mosaku O, Signolet J, Brennecke P, Kalkan T, Costello I, Humphreys P, Mansfield W, Nakagawa K, Strouboulis J, Behrens A, Bertone P, Hendrich B (2012). NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment. Cell Stem Cell 10 (5), 583-594.