Jason Signolet

Jason Signolet

2009 - 2013


Studentship Details

 

Dates of Study: Oct 2009 - Sept 2013

PhD Supervisor: Dr Brian Hendrich

Studentship Sponsor: Medical Research Council

Thesis Title: Control of self-renewal and pluripotency by the Mbd3/NuRD complex

 

Post PhD

When he finished his PhD in October 2013, Jason worked as a Research Assistant and then as a PostDoc in Dr Brian Hendrich's group at the Stem Cell Institute, University of Cambridge.

In November 2014, Jason moved to Australia and from January 2016 has been working as a Consulting Data Scientist at 'Data to Decisions Collaborative Research Centre' in Adelaide, Australia.

Plain English

I investigated the phenotype of Mbd3-deleted mouse embryonic stem cells. These cells have previously been shown to be resistant to differentiation in vitro and fail to form viable embryos in vivo. My data showed that, unlike wild type cells, these mutant cells do not follow an orderly differentiation trajectory. I have also identified a BMP signalling deficiency in these cells which may account for some of this behaviour.

Key Publications

  1. Reynolds N, Latos P, Hynes-Allen A, Loos R, Leaford D, O'Shaughnessy A, Mosaku O, Signolet J, Brennecke P, Kalkan T, Costello I, Humphreys P, Mansfield W, Nakagawa K, Strouboulis J, Behrens A, Bertone P, Hendrich B (2012). NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment. Cell Stem Cell 10 (5), 583-594.

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