2009 - 2013
Dates of Study: Oct 2009 - Sept 2013
Programme: Wellcome Trust 1+3 Programme in Stem Cell Biology
PhD Supervisor: Dr Thomas Down, Gurdon Institute
Studentship Sponsor: The Wellcome Trust
Thesis Title: Uncovering the roles of DNA methylation and histone modifications in maintaining pluripotency
Paulina is Founder and Chief Executive Officer of Cambridge Biolabs, a biotech start up company in Cambridge.
Image Legends (to the right)
Image 1: Differentially methylated region distribution in the genomic context of gene bodies.
Image 2: Differentially methylated region distribution in the genomic context of exons.
Image 3: Expression analysis of genes associated with differentially methylated regions.
My interest lies in how the epigenetic landscapes of pluripotent cells differ from those of committed cells and how these differences are created and maintained. I addressed these from both histone modification and DNA methylation point of view. This is a computationally driven project, exploiting published data resources and collaborations to improve our understanding of how epigenetics regulates pluripotency.
1) Wilson NK, Foster SD, Wang X, Knezevic K, Schütte J, Kaimakis P, Chilarska PM, Kinston S, Ouwehand WH, Dzierzak E, Pimanda JE, de Bruijn MF, Göttgens B. Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators. Cell Stem Cell. 2010 Oct 8;7(4):532-44. doi: 10.1016/j.stem.2010.07.016.