2010 - 2014
Dates of Study: Oct 2010 - Sept 2014
PhD Supervisor: Dr Ragnhildur Thóra Káradóttir
Studentship Sponsor: Gates Cambridge Trust
Thesis Title: Activity dependent neuron-glia interaction in health and disease
In April 2015, Sergey began his PostDoc career in the lab of Dr Andreas Hierlemann, at the ETH Zurich, Dept. of Biosystems Science & Engineering in Basel, Switzerland.
Normal brain function depends on oligodendrocytes wrapping myelin around nerve cell axons, to speed electrical signalling. When myelin is lost in diseases, causing mental and physical impairment, oligodendrocyte precursor cells (OPCs) can remyelinate axons, but this process often fails. In my PhD research I used electrical recordings from nerve cells and OPCs, in culture and in brain slices, to study how growth factors and neurotransmitters regulate the ability of OPCs to carry out myelination and remyelination (assessed using immunocytochemistry). The long-term aim is to provide therapeutic approaches to repairing damaged myelin in diseases like multiple sclerosis.
- Tyzack GE, Sitnikov S, Barson D, Adams-Carr KL, Lau NK, Kwok JC, Zhao C, Franklin RJM, Karadottir RT, Fawcett JW, et al. (2014). Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression. Nat. Commun. 5, 4294.