Sergey Sitnikov

Sergey Sitnikov

2010 - 2014

Dates of Study: Oct 2010 - Sept 2014

PhD Supervisor: Dr Ragnhildur Thóra Káradóttir

Studentship Sponsor: Gates Cambridge Trust

Thesis Title: Activity dependent neuron-glia interaction in health and disease

Post PhD

In April 2015, Sergey began his PostDoc career in the lab of Dr Andreas Hierlemann, at the ETH Zurich, Dept. of Biosystems Science & Engineering in Basel, Switzerland.

Plain English

Normal brain function depends on oligodendrocytes wrapping myelin around nerve cell axons, to speed electrical signalling. When myelin is lost in diseases, causing mental and physical impairment, oligodendrocyte precursor cells (OPCs) can remyelinate axons, but this process often fails. In my PhD research I used electrical recordings from nerve cells and OPCs, in culture and in brain slices, to study how growth factors and neurotransmitters regulate the ability of OPCs to carry out myelination and remyelination (assessed using immunocytochemistry). The long-term aim is to provide therapeutic approaches to repairing damaged myelin in diseases like multiple sclerosis.

Key Publications

  1. Tyzack GE, Sitnikov S, Barson D, Adams-Carr KL, Lau NK, Kwok JC, Zhao C, Franklin RJM, Karadottir RT, Fawcett JW, et al. (2014). Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression. Nat. Commun. 5, 4294.

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