2011 - 2015
In June 2015, Stan moved to Columbia University College of Physicians and Surgeons, New York, USA to complete the remainder of his MD via funding from the NIH MD/PhD programme.
For my PhD, genome editing in embryonic stem cells was used to create a cancer-inspired mutation in the epigenetic regulator, Ezh2. This resulted in an unexpected priming of cells towards specific lineage commitment even in a pluripotent state—along with upon differentiation—indicating a higher role for epigenetic determinants in the hierarchy of gene expression control. Furthermore, this work demonstrates that redeployment of epigenetic marks by genome editing can be used to guide cell fate.