Stan Wang

Stan Wang

2011 - 2015

Studentship Details


Dates of Study: Oct 2011 - Jul 2015

PhD Supervisor: Professor Roger Pedersen (and Sir John Gurdon)

Studentship Sponsor: Gates Cambridge Trust & NIH Oxford-Cambridge MD/PhD Programme

Thesis Title: Reprogramming and epigenetic factors regulating pluripotency and the stem cell state.

Post PhD

In June 2015, Stan moved to Columbia University College of Physicians and Surgeons, New York, USA to complete the remainder of his MD via funding from the NIH MD/PhD programme.

Plain English

For my PhD, genome editing in embryonic stem cells was used to create a cancer-inspired mutation in the epigenetic regulator, Ezh2. This resulted in an unexpected priming of cells towards specific lineage commitment even in a pluripotent state—along with upon differentiation—indicating a higher role for epigenetic determinants in the hierarchy of gene expression control. Furthermore, this work demonstrates that redeployment of epigenetic marks by genome editing can be used to guide cell fate.

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