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Wellcome - MRC Cambridge Stem Cell Institute

 

Doug Winton 2017Professor Doug Winton

Intestinal stem cells

Laboratory Location: Cancer Research UK Cambridge Research Institute (CR-UK CRI)

Professor of Epithelial Biology 

 

 

Research

Renewing tissues and many cancers are maintained by a small number of long-lived stem cells. Most models of stem cell organisation take account of their longevity and assume that they are stable populations carrying unique identifying characteristics. 

However, this interpretation now seems too simplistic. For example the active signalling pathways that together define signatures of stem cells may not be as stable over time as previously thought. 

Our approach is pragmatic: to identify novel ways of assaying stem cells in situ with respect to the functional behaviours that are integral to their biology. The objective is to quantitatively describe how such behaviours allow somatic variants to become fixed, spread within the tissue and ultimately undergo neoplastic transformation

 

External links

www.cruk.cam.ac.uk/research-groups/winton-group 

https://crukcambridgecentre.org.uk/users/dougwinton

 

CSCI collaborators

Ben Simons