Professor Christine Watson
Stem cell and lineage determining factors in mammary gland
Laboratory Location: Cambridge Cancer Centre
Departmental Affiliation: Department of Pathology
Research
We are interested in identifying transcriptional regulators that control lineage commitment of mammary stem cells. We have identified a novel gene, Zfp157, that is a master regulator of the alveolar lineage. Further work is focussed on lineage tracing using fluorescent fusion proteins and H2B-GFP to isolate and characterise long label-retaining cells.
The Running Rainbow: Depth coding confocal image of a branching mammary duct. Image credit: Bethan Lloyd-Lewis, Felicity Davis, Olivia Harris
External links
www.path.cam.ac.uk/directory/christine-watson
www.cambridgecancercentre.org.uk/users/cjwatson