Dr Elisa Laurenti
Human haematopoietic stem cells biology in health and disease
Laboratory: Cambridge Stem Cell Institute, Clifford Allbutt Building, Cambridge Biomedical Campus. Departmental Affiliation: Haematology
Elisa Laurenti completed her PhD under the supervision of Prof. Andreas Trumpp in Lausanne, Switzerland. In 2010 she joined Dr John Dick’s laboratory in the University of Toronto where she became interested in the study of human hematopoietic stem cells. She established her own research group at the Cambridge Stem Cell Institute in 2014.
European Haematology Association, Wellcome Trust
A colony of different blood cells arising from a single adult human hematopoietic stem cell. (Credit Antonella Santoro)
Haematopoietic stem cells (HSC) are responsible for life-long blood production. They are the best-studied stem cell type owing to decades of research with animal models. Despite the high incidence of blood-related diseases, and accumulating evidence that certain aspects of HSC biology are species-specific, very little is known on human HSC. My laboratory develops integrated approaches combining in vitro and in vivo single cell assays, transcriptomics and bioinformatics to study human HSC and progenitor cells. We are currently investigating how cell cycle regulation, inflammation and ageing, processes intimately linked to disease initiation, affect human HSC unique molecular and functional properties. Understanding how the cellular and molecular composition of the HSC/progenitor compartment changes in stress conditions and throughout a human lifetime has important implications for regenerative medicine and treatment of blood cancers.
Serena Belluschi, Emily Calderbank, Valerio Ciaurro, Alexander Kaden Kheirallah, Myrna Maquinana, Priyanka Tibarewal.
If you are interested in working with us, please contact us at firstname.lastname@example.org, we are always looking for smart motivated people to join our team.
Every day a trillion blood cells are produced in our body. This amazing turnover is achieved thanks to blood stem cells. These cells have the unique capacity to produce all blood cells in healthy individuals but also after injury or infection. Their function is vital, because if impaired, either blood production fails or cancer arises. Our laboratory thus focuses on these 2 important questions:
- How are human blood stem cells different from other blood cell types?
- What is the impact of age and disease on human blood stem cell function? For this we measure human blood stem cell responses to a number of signals, compare them to other blood cells and identify specific genes that regulate their behaviour. We also study what goes wrong in blood stem cells when there is inflammation, in the elderly and during the early stages of cancer development. Understanding how blood formation occurs in humans in all of these contexts we hope will help design new therapies against a range of diseases.
- Laurenti E*, Frelin C*, Xie S*, Ferrari R, Dunant CF, Zandi S, Neumann A, Plumb I, Doulatov S, Chen J, April C, Fan J-B, Iscove N, Dick JE. CDK6 Levels Regulate Quiescence Exit in Human Hematopoietic Stem Cells. Cell Stem Cell, 2015 Feb 19; 16 (3):302-313. PMCID:PMC4359055 * equal contribution
- Laurenti E, Doulatov S, Zandi S, Plumb I, Chen J, April C, Fan J-B, Dick JE. The transcriptional architecture of human hematopoiesis identies multilevel control of lymphoid commitment. Nature Immunology, 2013 Jul; 14(7): 756-63. PMID:23708252
- Notta F*, Doulatov S*, Laurenti E, Poeppl A, Jurisica I, Dick JE. Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment. Science, 2011 Jul 8; 333(6039):218-21. PMID:21737740 * equal contribution
- Laurenti E, Varnum-Finney B, Wilson A, Ferrero I, Blanco-Bose WE, Ehninger A, Knoepfler PS, Cheng PF, MacDonald HR, Eisenman RN, Bernstein ID, Trumpp A. Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity. Cell Stem Cell, 2008 Dec 4;3(6):611-24. PMCID:PMC2635113
- Wilson A, Laurenti E, Oser G, van der Wath R, Blanco-Bose WE, Jaworski M, Offner S, Dunant CF, Eshkind L, Bockamp E, Lio P, MacDonald HR, Trumpp A. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell, 2008, Dec 12;135(6):1118-29. PMID:19062086