The Stem Cell Institute comprises:

Anne McLaren Laboratory for Regenerative Medicine (LRM)

Wellcome Trust Centre for Stem Cell Research (CSCR)

along with stem cell research groups in University Departments, research institutes and affiliated institutions.

Welcome to the Cambridge Stem Cell Institute

We draw together outstanding researchers from 25 stem cell laboratories in Cambridge to form a world-leading centre for stem cell biology and medicine. Scientists in the Institute collaborate to generate new knowledge and understanding of the biology of stem cells and provide the foundation for new medical treatments.

Fig. 1: Inhibitors of the Mek/Erk and GSK3 pathways (2i) in the absence of serum promote the generation of induced pluripotent stem (iPS) cell colonies, shown here. These cells show expression of a pluripotency reporter (green) and reactivation of the silent X chromosome, as demonstrated by the lack of the nuclear red staining body (trimethyl H3K27). For comparison, a cluster of non-reprogrammed cells (non-green) displaying a silent X chromosome (red nuclear body) is shown in the bottom right-hand corner.

Expression of a pluripotency reporter,

Dr Josè Silva