Biography
Charlotte earned her degree in Biology in Bristol in 2014. She spent a year as a microbiologist in the Pharma industry but soon realised her interests were in academic research. This brought her to the Wellcome Sanger Institute in 2015, where she first worked within the cancer genomics programme, developing skills in tissue culture, drug testing and organoid work. She then moved to the parasites and microbes programme, where she was involved in projects investigating different pathogens including Vibrio cholerae (cholera), Treponema pallidum (syphilis), Trypanosoma brucei (trypanosomiasis), Schistosoma mansoni (schistosomiasis) and Trichuris spp (trichuriasis), which brought her to the Duque-Correa group at CSCI in 2022. Charlotte is the lab manager of the team. Within the group, she leads on multiple projects and collaborations, studying the host-parasite interactions of whipworms in the gut utilising both in vivo and in vitro models as well as an extensive range of cellular and molecular biology techniques.
Publications
Stark, KA., Rinaldi, G., Costain, A., Clare, S., Tolley, C., [+12 authors]. (2024) Gut microbiota and immune profiling of microbiota-humanised versus wildtype mouse models of hepatointestinal schistosomiasis. anim microbiome 6(36). DOI: 10.1186/s42523-024-00318-3
Bashi, AC., [+25 authors], Tolley, C., [+10 authors]. (2024) Large-scale pan-cancer cell line screening identifies actionable and effective drug combinations. Cancer discovery 14(5):846-865. DOI: 10.1158/2159-8290.CD-23-0388
Randzavola, LO., [+8 authors], Tolley, C., [+25 authors]. (2022) EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling. Elife. 11:e76387. DOI: 10.7554/eLife.76387
Cortés, A., [+7 authors], Tolley, C., [+5 authors] (2022) The gut microbial metabolic capacity of microbiome-humanized vs. wild type rodents reveals a likely dual role of intestinal bacteria in hepato-intestinal schistosomiasis. PLoS neglected tropical diseases 16(10):e0010878. DOI: 10.1371/journal.pntd.0010878
Duque-Correa, MA., [+12 authors], Tolley, C., [13 authors] (2022) Defining the early stages of intestinal colonisation by whipworms. Nat. commun. 13(1):1725. DOI: 10.1038/s41467-022-29334-0
Jaaks, P., [+17 authors] , Tolley, C., [+9authors] (2022) Effective drug combinations in breast, colon and pancreatic cancer cells. Nature. 603(7899):166-173. DOI: 10.1038/s41586-022-04437-2
Autheman, D., Crosnier, C., Clare, S., Goulding, D.A., Brandt, C., Harcourt, K., Tolley, C., [+7 authors] (2021). An invariant Trypanosoma vivax vaccine antigen induces protective immunity. Nature. 595(7865):96–100. DOI: 10.1038/s41586-021-03597-x
Wang, D., [+4 authors], GDSC Screening Team, [+5 authors] (2020). A statistical framework for assessing pharmacological responses and biomarkers using uncertainty estimates. Elife. 9:e60352. DOI: 10.7554/eLife.60352
Cortés, A., [+6 authors] , Tolley, C., [+6 authors]. (2020). Baseline Gut Microbiota Composition Is Associated With Schistosoma mansoni Infection Burden in Rodent Models. Front. Immunol. 11:593838. DOI: 10.3389/fimmu.2020.593838
Dorman, MJ., Domman, D., Poklepovich, T., Tolley, C., [+13 authors]. (2020). Genomics of the Argentinian cholera epidemic elucidate the contrasting dynamics of epidemic and endemic Vibrio cholerae. Nat. commun. 11(1):4918. DOI: 10.1038/s41467-020-18647-7
Goncalves, E., [+15 authors] , Tolley, C., [+11 authors]. (2020). Drug mechanism‐of‐action discovery through the integration of pharmacological and CRISPR screens. Mol. Syst. Biol. 16(7):e9405. DOI: 10.15252/msb.20199405
Forbester, JL., [+7 authors] , Tolley, C., [+7 authors]. (2020). IRF5 promotes influenza virus-induced inflammatory responses in human induced pluripotent stem cell-derived myeloid cells and murine models. J. Virol. 94(9):e00121-20. DOI: 10.1128/JVI.00121-20
