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Research Themes

Stem cells have the extraordinary ability to develop into any type of cell in the body. Stem cells are found in developing embryos and also in adults in tissues including the brain, bone marrow, skin and liver.

Our research at the Cambridge Stem Cell Institute falls into three broad themes: Stem Cell States, Stem Cells in Disease, Stem Cells & Therapeutics. Many of our scientists contribute to more than one theme, and within these themes we have particular strengths in pluripotency, haematopoiesis, neural and epithelial stem cells.

Theme 1: Stem Cell States

We study the fundamental biology of pluripotent and adult stem cells to understand the mechanisms by which they self-renew, maintain their states and commit to differentiate into all the cell types of the body. We aim to achieve new insight into these long-standing issues through a programme of innovative and cross-disciplinary investigation that integrates knowledge at multiple scales across different tissues and organisms.

Theme 2: Stem Cells in Disease

Many disease states arise (malignancies) or persist (regeneration failure) as a result of stem and progenitor cell dysfunction. Underpinned by our exploration of normal stem cell states, we are investigating the mechanisms responsible for pathological behaviours of stem and progenitor cells. We focus particularly on malignancy and regenerative failure, in studies which are laying the foundation for new approaches to diagnosis and treatment.

Theme 3: Stem Cells & Therapeutics

We exploit the potential of stem cells to model diseases in vitro and to generate new diagnostic and therapeutic approaches. Patient-derived induced pluripotent stem cells and organoids, combined with advanced genome engineering technology, provide excellent platforms for studying human diseases in vitro. In addition several investigators are developing first-in-human clinical trials of cellular therapies using stem cell derivatives.