Course Specific Training ~ 60 hours:
THEME 1: Stem Cell States
Introduction to Key Concepts of Stem Cell Biology
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Stem cell potency and fate
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Stem cell assays and purification, lessons from blood
- Stem cell niches
- Mapping human cell states in health and disease
From Pluripotency to Gastrulation
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Insights from non-human primate studies
- Self-organization and stem cell derived embryo models
THEME 2: Stem Cells in Disease
Stem Cells and Cancer
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When maintenance of the Oesophagus Epithelium goes awry
- Molecular alterations in Leukaemia
Stem Cells and Ageing
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Competition of stem cell clones as a prelude to cancer
- Experimental models to study ageing processes
Normal and Malignant Blood Stem Cells
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Epigenomic approaches towards leukaemia stem cell eradication
- How to discover new drugs targeting normal/malignant stem cells
Intestinal stem cell biology in health, infection and inflammatory diseases
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How a biobank of patient derived organoids can help treating inflammatory bowel disease
- How parasitic worms reset intestinal stem cell function
THEME 3: Stem Cells and Therapeutics
The Biology of Regeneration
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From model organisms to human digit regeneration
- Progress and challenges for heart regeneration
Translation of Stem Cell Therapies to the Brain
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Cell Therapy for Parkinson Disease
- Mapping and modulating the cellular environment of the brain
Regenerative Medicine and Cell Therapy
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Cell therapy for heart failure – lessons learned and the road ahead
- From lab produced blood cells to clinical application
- Cell therapy for liver disease
Neural Stem Cells
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Tackling Multiple Sclerosis by stimulating endogenous repair
Plus attendance at regular internal and International seminars, hosted by the Cambridge Stem Cell Institute.
Transferable Skills Training ~30 hours:
THEME 4:
Biostatistics Course
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Matt Castle to deliver computational course (expected 2 days of training)
- Additional BioInformatics discussions with our DRP Computational Scientists (Melania, Andrian and Nadav) with expertise in single cell genomics (Andrian), spatial biology (Nadav), and dynamic systems scale modelling (Melania).
Big Techniques
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Imaging
- Flow Cytometry, basics of immunostaining
- Single cell sequencing
Data Management
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Facilitated by central ‘Research Data Management’ team
Working with primary human samples
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general overview of HTA principles, respect for donations, regulation, human embryonic research
Routes to Commercialisation
Animal Research
Patient and Public Involvement and Engagement
Scientific Writing