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Stem Cells in Disease

Stem cells in Disease

Stem cell dysfunction underlies a range of diseases and health challenges that face the global population today. From neurodegenerative and cardiovascular diseases to cancer and ageing, stem cell dysregulation is implicated across the disease spectrum.

Underpinned by our exploration of normal stem cell states, we are investigating the mechanisms responsible for pathological behaviours of stem and progenitor cells. Our researchers focus particularly on different cancer pathophysiology and regenerative failure.

The Institute has a range of group leaders working across different topics within the stem cells in disease theme, details listed below. More information on each researcher's specific area can be found on their group pages.

 

107-Barker 2017

Professor Roger Barker

Parkinson's and Huntington's disease

 

Key diseases: Parkinson's disease & Huntington's disease  

Buczaki Simon 128

Dr Simon Buczacki

Colorectal cancer cell identity and tumour evolution

Key disease: Colorectal cancer

128-Franklin 2017

Prof Robin Franklin

Studying neural stem cells and central nervous system regeneration.                             

Key disease: Multiple sclerosis

107-Gottgens-2017

Prof Bertie Göttgens

Understanding cellular decision making in normal and leukaemic blood stem cells.

Key disease: Leukaemia

107-Green-2017

Prof Tony Green

Establishing how blood stem cells are subverted in blood cancers.

Key disease: Myeloproliferative neoplasms

107-Hodson-2017

Dr Daniel Hodson

Mutation timing in lymphomagenesis

 

Key disease: Lymphoma

107-Huntly-2017

Prof Brian Huntly

Leukaemia stem cell biology and leukaemogenesis

Key diseases: Leukaemia and Lymphoma

107-Karadottir-2017

Dr Ragnhildur Thóra Káradóttir

Researching how brain stem cells decide to become myelinating cells and how they can be manipulated to repair myelin in disease.

 

Key disease: Multiple sclerosis

107-Laurenti-2017

Dr Elisa Laurenti

Investigating human blood stem cells biology in health and disease.

Key diseaseLeukaemia

107-McCaskie 2017

Prof Andrew McCaskie                   

Regenerative therapies for bone and cartilage repair

 

Key diseaseArthritis

107-Mendez-Ferrer-2017

Dr Simón Méndez-Ferrer

Focusing on blood stem cells and their environment in health and disease.               

107-Ringshausen-2017

Dr Ingo Ringshausen

Haematopoietic stem cells and malignancies

 

Key diseasesLeukaemia and Lymphoma

107-Rowitch-2017

Prof David Rowitch

Investigating how genes determine development and diversity of glial cells in the brain.

Key disease: Pelizaeus-Merzbacher disease 

107-Sinha-2017

Dr Sanjay Sinha

Vascular diseases

 

Key disease: Cardiovascular disease                                                                                                                       

107-Vassiliou-2017

Professor George Vassiliou

Leukaemic haemopoietic stem cells

 

Key diseaseLeukaemia