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Stem Cells in Disease

Stem cells in Disease

Stem cell dysfunction underlies a range of diseases and health challenges that face the global population today. From neurodegenerative and cardiovascular diseases to cancer and ageing, stem cell dysregulation is implicated across the disease spectrum.

Underpinned by our exploration of normal stem cell states, we are investigating the mechanisms responsible for pathological behaviours of stem and progenitor cells. Our researchers focus particularly on different cancer pathophysiology and regenerative failure.

The Institute has a range of group leaders working across different topics within the stem cells in disease theme, details listed below. More information on each researcher's specific area can be found on their group pages.


107-Barker 2017

Professor Roger Barker

Parkinson's and Huntington's disease


Key diseases: Parkinson's disease & Huntington's disease  

Buczaki Simon 128

Dr Simon Buczacki

Colorectal cancer cell identity and tumour evolution

Key disease: Colorectal cancer

128-Franklin 2017

Prof Robin Franklin

Studying neural stem cells and central nervous system regeneration.                             

Key disease: Multiple sclerosis


Prof Bertie Göttgens

Understanding cellular decision making in normal and leukaemic blood stem cells.

Key disease: Leukaemia


Prof Tony Green

Establishing how blood stem cells are subverted in blood cancers.

Key disease: Myeloproliferative neoplasms


Dr Daniel Hodson

Mutation timing in lymphomagenesis


Key disease: Lymphoma


Prof Brian Huntly

Leukaemia stem cell biology and leukaemogenesis

Key diseases: Leukaemia and Lymphoma


Dr Ragnhildur Thóra Káradóttir

Researching how brain stem cells decide to become myelinating cells and how they can be manipulated to repair myelin in disease.


Key disease: Multiple sclerosis


Dr David Kent

Understanding single cell fate choice in normal and cancerous stem cells.

Key disease: Myeloproliferative Neoplasms


Dr Elisa Laurenti

Investigating human blood stem cells biology in health and disease.

Key disease: Leukaemia

107-McCaskie 2017

Prof Andrew McCaskie                   

Regenerative therapies for bone and cartilage repair


Key disease: Arthritis



Dr Simón Méndez-Ferrer

Focusing on blood stem cells and their environment in health and disease.


Dr Ingo Ringshausen

Haematopoietic stem cells and malignancies


Key diseases: Leukaemia and Lymphoma


Prof David Rowitch

Investigating how genes determine development and diversity of glial cells in the brain.

Key disease: Pelizaeus-Merzbacher disease                                                                                                                        


Dr Sanjay Sinha

Vascular diseases


Key disease: Cardiovascular disease


Dr George Vassiliou

Leukaemic haemopoietic stem cells


Key disease: Leukaemia