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Cambridge Stem Cell Institute

myelination in cerebelllum

Stem cell dysfunction underlies a range of diseases and health challenges that face the global population today. From neurodegenerative and cardiovascular diseases to cancer and ageing, stem cell dysregulation is implicated across the disease spectrum.

Underpinned by our exploration of normal stem cell states, we are investigating the mechanisms responsible for pathological behaviours of stem and progenitor cells. Our researchers focus particularly on different cancer pathophysiology and regenerative failure.

The Institute has a range of group leaders working across different topics within the stem cells in disease theme, details listed below. More information on each researcher's specific area can be found on their group pages.


Professor Roger Barker

Parkinson's and Huntington's disease

Key diseases: Parkinson's disease & Huntington's disease  

Prof Bertie Göttgens

Understanding cellular decision making in normal and leukaemic blood stem cells.

Key disease: Leukaemia  

Dr Daniel Hodson

Mutation timing in lymphomagenesis

Key disease: Lymphoma

Prof Tony Green

Establishing how blood stem cells are subverted in blood cancers.

Key disease: Myeloproliferative neoplasms

Dr Ragnhildur Thóra Káradóttir

Researching how brain stem cells decide to become myelinating cells and how they can be manipulated to repair myelin in disease.

Key disease: Multiple sclerosis

Prof Brian Huntly

Leukaemia stem cell biology and leukaemogenesis

Key diseases: Leukaemia and Lymphoma

Prof Andrew McCaskie                   

Regenerative therapies for bone and cartilage repair

Key diseaseArthritis

Dr Elisa Laurenti

Investigating human blood stem cells biology in health and disease.

Key diseaseLeukaemia

Dr Simón Méndez-Ferrer

Focusing on blood stem cells and their environment in health and disease 

Dr Sanjay Sinha

Vascular diseases

Key disease: Cardiovascular disease       

Prof David Rowitch

Investigating how genes determine development and diversity of glial cells in the brain.

Key disease: Pelizaeus-Merzbacher disease 

Dr Kostas Tzelepis 

Cancer, Ageing, RNA modifications

Key disease: Leukaemia 

Professor George Vassiliou

Leukaemic haemopoietic stem cells

Key diseaseLeukaemia