Stem cell states

Stem cells have the extraordinary ability to develop into any type of cell in the body. We study the fundamentals of stem cell biology to understand the mechanisms by which they self-renew, maintain their states and commit to differentiate into all the cell types of the body.

Establishing new understanding of stem cell biology and behaviour complements and informs our studies of stem cell dysfunction in disease and provides the foundation of our translational aspirations for stem cells and therapeutics.

The Institute has a range of group leaders working across different topics within the stem cell states theme, details listed below. More information on each researcher's specific area can be found on their group pages.

	Dr Maria Alcolea Understanding epithelial cell fate using the oesophagus as a model system.
	Prof Bertie Göttgens Understanding cellular decision making in normal and leukaemic blood stem cells.
	Dr Ragnhildur Thóra Káradóttir Researching how brain stem cells decide to become myelinating cells and how they can be manipulated to repair myelin in disease.
	Dr Elisa Laurenti Investigating human blood stem cells biology in health and disease.
	Dr Simón Méndez-Ferrer Focusing on blood stem cells and their environment in health and disease.
	Prof Anna Philpott Researching the mechanisms driving cellular decision-making in health and disease.
	Prof Ben Simons Tracing stem cell fate in development, maintenance and disease.
	Dr Kostas Tzelepis  Studying stem cells in Cancer, Ageing, and RNA modifications