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Stem Cell States

Stem Cell States

Stem cells have the extraordinary ability to develop into any type of cell in the body. We study the fundamentals of stem cell biology to understand the mechanisms by which they self-renew, maintain their states and commit to differentiate into all the cell types of the body.

Establishing new understanding of stem cell biology and behaviour complements and informs our studies of stem cell dysfunction in disease and provides the foundation of our translational aspirations for stem cells and therapeutics.

The Institute has a range of group leaders working across different topics within the stem cell states theme, details listed below. More information on each researcher's specific area can be found on their group pages.

128-Alcolea 2017

Dr Maria Alcolea

Understanding epithelial cell fate using the oesophagus as a model system.

     

Basu Srinjan

Dr Srinjan Basu

Using advanced single-cell imaging to study stem cell biology.

128-Chalut 2017

Dr Kevin Chalut

Developing novel biotechnology to investigate physical states of stem cells.

 

128-Cvejic 2017

Dr Ana Cvejic

Discovering how blood stem cells differentiate into diverse cell types.

128-Franklin 2017

Prof Robin Franklin

Studying neural stem cells and central nervous system regeneration.

107-Gottgens-2017

Prof Bertie Göttgens

Understanding cellular decision making in normal and leukaemic blood stem cells.

107-Green-2017

Prof Tony Green

Establishing how blood stem cells are subverted in blood cancers.

107-Hendrich-2017

Dr Brian Hendrich

Studying how genetic changes underpin stem cell fate decisions.

107-Karadottir-2017

Dr Ragnhildur Thóra Káradóttir

Researching how brain stem cells decide to become myelinating cells and how they can be manipulated to repair myelin in disease.

107-Laurenti-2017

Dr Elisa Laurenti

Investigating human blood stem cells biology in health and disease.

107-Lee-2017

Dr Joo-Hyeon Lee

Studying how stem cells respond to environmental stimuli using the lung as a model system.

107-Mendez-Ferrer-2017

Dr Simón Méndez-Ferrer

Focusing on blood stem cells and their environment in health and disease.                                                                                                                     

Nichols Jenny 128

Prof Jennifer Nichols

Understanding stem cell biology in embryonic development.

107-Philpott-2017

Prof Anna Philpott

Researching the mechanisms driving cellular decision-making in health and disease.

107-Rowitch-2017

Prof David Rowitch

Investigating how genes determine development and diversity of glial cells in the brain.

107-Silva-2017

Dr José Silva

Studying how cells can be reprogrammed into a naïve stem cell state.

107-Simons-2017

Prof Ben Simons

Tracing stem cell fate in development, maintenance and disease.

Smith Austin 128.jpg

Prof Austin Smith

Understanding how stem cells can generate all other cell types in the body.

107-Vallier-2017

Prof Ludovic Vallier

Researching how stem cells become adult tissues, including liver pancreas and lung.