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Wellcome-MRC Cambridge Stem Cell Institute

 
Read more at: Research shows early embryo similarities across six different mammal species

Research shows early embryo similarities across six different mammal species

20 June 2022

A cross-species analysis of energy metabolism in mammalian embryogenesis Cells of the early mammalian embryo face a unique challenge: to produce large numbers of progeny quickly while regulating appropriate cell differentiation in a short amount of time. The regulation of energy metabolism is crucial for these processes...


Read more at: Molecular 3D-maps unlock new ways of studying human reproduction
Laser assisted analysis of a marmoset embryo after implantation. Image shows gene activity for SOX2, one of the earliest indicators for head formation. Credit U of Cambr

Molecular 3D-maps unlock new ways of studying human reproduction

16 June 2022

Scientists have identified the biochemical signals that control the emergence of the body pattern in the primate embryo. This will guide work to understand birth defects and pregnancy loss in humans. The study also provides a crucial reference for foetal tissue generation in the lab. Such tissue is in short supply but is...


Read more at: Scientists uncover unique features of rare blood stem cells across the human body
Graphical abstract

Scientists uncover unique features of rare blood stem cells across the human body

9 June 2022

Our body produces one trillion new blood cells each day, a process driven by rare haematopoietic stem and progenitor cells (HSPC) inside the bone marrow. A new paper demonstrates that even rarer HSPCs with unique features also exist in other human organs. This work, from the Wellcome-MRC Cambridge Stem Cell Institute (CSCI...


Read more at: Impact of DNA mutations on lifelong blood cell production uncovered
Expanding populations of blood cells. Credit Karen Arnott EMBL-EBI

Impact of DNA mutations on lifelong blood cell production uncovered

6 June 2022

Researchers discover how leukaemia-associated gene mutations steadily commandeer blood cell production over a lifetime, and how these changes relate to ageing and cancer development. New research has uncovered how genetic mutations hijack the production of blood cells in different periods of life. Scientists at the...


Read more at: Cellular secrets of ageing unlocked by researchers
Blood cells. Credit Anirudh

Cellular secrets of ageing unlocked by researchers

1 June 2022

Researchers have discovered how genetic mutations accumulated slowly over a lifetime lead to dramatic changes in blood formation after 70, providing a new theory for ageing New research has uncovered how genetic changes that accumulate slowly in blood stem cells throughout life are likely to be responsible for the dramatic...


Read more at: CSCI Welcomes Dr Richard Tyser as Group Leader
Richard Tyser to join CSCI

CSCI Welcomes Dr Richard Tyser as Group Leader

19 April 2022

Dr Richard Tyser will join Cambridge Stem Cell Institute as a Principal Investigator this summer, bringing his expertise on the emergence of form and function during early heart development. Dr Tyser is coming from his post at the University of Oxford in the Department of Physiology, Anatomy and Genetics, where in 2018 he...


Read more at: New research details communication between nerves and bone

New research details communication between nerves and bone

10 March 2022

A new study was published today (10 March) in Cell Stem Cell , answering a question that’s been sitting unanswered for over thirty years. The research, led by Professor Simón Méndez-Ferrer’s Lab at Wellcome-MRC Cambridge Stem Cell Institute (CSCI), finally identified Interleukin-6 as a driver of an important switch that...


Read more at: Mapping the way to improved transfusion products
Megakaryocytes produced from human pluripotent stem cells

Mapping the way to improved transfusion products

7 March 2022

Research finds identifiers that can speed the process of in-vitro platelet production A new paper from the Wellcome-MRC Cambridge Stem Cell Institute (CSCI) and the UK Regenerative Medicine Platform has identified previously unknown markers of cells called megakaryocyte progenitors. This discovery will lead to better...


Read more at: Research Provides New Explanation for Cell Organisation in Early Embryo Development
siRNA-treated ES cells

Research Provides New Explanation for Cell Organisation in Early Embryo Development

23 February 2022

New research from the Wellcome-MRC Cambridge Stem Cell Institute (CSCI) and the Department of Physiology, Development, and Neuroscience at the University of Cambridge (PDN) explores the self-organisation of tissues in early embryos, offering an explanation for how cells sort themselves as they develop. The paper, published...


Read more at: Welcoming Dr Konstantinos Tzelepis to our Team of Principal Investigators
Kostas Tzelepis

Welcoming Dr Konstantinos Tzelepis to our Team of Principal Investigators

22 February 2022

Dr Konstantinos Tzelepis will join Cambridge Stem Cell Institute as a Principal Investigator, with research focusing on RNA modifications in stem cell homeostasis. ​ ​ Dr Tzelepis will be moving from The Milner Therapeutics Institute , where he also served as a PI. Prior to his appointment at Milner, he was a Wellcome...