Dr Richard Tyser
Email: rt593@cam.ac.uk
Laboratory: Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre
Biography
Richard’s research focuses on the emergence of form and function during early heart development. He did his undergraduate degree at the University of Manchester, undertaking a placement year at the University of Nevada, Reno (USA) investigating cAMP signalling in cardiomyocytes with Professor Robert Harvey. He received his PhD in Cardiovascular Medicine from University College London in 2016, having completed a British Heart Foundation 4 year PhD Programme with Professor Paul Riley and Professor Sean Davidson, investigating how the onset of cardiac function influences subsequent heart development. After his PhD, he took up a post-doctoral position with Professor Shankar Srinivas at the University of Oxford, as part of Wellcome Trust funded consortium studying gastrulation. In 2018, he was awarded a British Heart Foundation Immediate Basic Research Fellowship to study how the first heartbeat is initiated.
Key Publications
- Tyser RCV, Mahammadov E, Nakanoh S, Vallier L, Scialdone A, Srinivas S. “Single cell transcriptomic characterisation of a gastrulating human embryo” Nature (2021) 600;285–289.
- Tyser RCV, Ibarra-Soria X, McDole K, Jayaram S, Godwin J, van den Brand T, Miranda A, Scialdone A, Keller PJ, Marioni JC, Srinivas S. “Characterization of a common progenitor pool of the epicardium and myocardium” Science (2021) 371.
- Tyser RCV, Miranda A, Chen C, Davidson SM, Srinivas S, Riley PR. "Calcium handling precedes cardiac differentiation to initiate the first heartbeat" eLIFE (2016) 5:e17113 PMC5059139
- Pijuan-Sala B, Griffiths J, Guibentif C, Hiscock TW, Jawaid W, Calero-Nieto FJ, Mulas C, Ibarra-Soria X, Tyser RCV, Ho DLL, Reik W, Srinivas S, Simons BD, Nichols J, Marioni JC, Göttgens B. “A singlecell molecular map of mouse gastrulation and early organogenesis” Nature (2019) 566(7745):490- 495