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Wellcome-MRC Cambridge Stem Cell Institute


Dr Kristian Franze

CNS development and disease

Departmental Affiliation: Department of Physiology, Development and Neuroscience



Mechanobiology of nervous system development and pathology. We are taking an interdisciplinary approach to investigate how cellular forces, local cell and tissue compliance and cellular mechanosensitivity contribute to CNS development and disease. Methods we are exploiting include atomic force microscopy, traction force microscopy, custom-built soft cell culture substrates, substrate patterning, and cell and molecular biological techniques. We are mostly interested in the early development of the African clawed frog Xenopus laevis.


Additional links

Cambridge Neuroscience page 

Max-Planck page 


CSCI collaborators

Thora Karadottir

Mekayla Storer 

Key Publications