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Cambridge Stem Cell Institute

 
Read more at: Brain Cells Created from Patient's Skin
Brain Cells Created from Patient's Skin

Brain Cells Created from Patient's Skin

17 November 2016

Cambridge scientists have, for the first time, created cerebral cortex cells – those that make up the brain’s grey matter – from a small sample of human skin. The researchers’ findings, which were funded by Alzheimer’s Research UK and the Wellcome Trust, were published today in Nature Neuroscience . Diseases of the...


Read more at: Smooth muscle cells created from patients’ skin cells
Smooth muscle cells created from patients’ skin cells

Smooth muscle cells created from patients’ skin cells

17 November 2016

Cambridge scientists have used skin stem cells to create vascular smooth muscle cells, which make up the walls of blood vessels. This research could pave the way to new treatments and better screening for cardiovascular disease. Read the full story on the University website.


Read more at: Breakthrough on MS Cure
Breakthrough on MS Cure

Breakthrough on MS Cure

17 November 2016

Stem Cell researchers at Cambridge and Edinburgh have discovered a promising stem cell therapy for multiple sclerosis. While much work is still needed to translate the discovery into an effective treatment, this breakthrough provides a promising road map towards a cure. A video story featuring the SCI's Robin Franklin can...


Read more at: Stem cell function and stress response are controlled by protein synthesis
Stem cell function and stress response are controlled by protein synthesis

Stem cell function and stress response are controlled by protein synthesis

16 November 2016

New article from the Frye Lab published in Nature Elevated protein synthesis and increased cell division rates are key physiological tasks for cancer cells and the protein translation machinery emerged as promising therapeutic target to control tumour growth. However, our study reveals that skin stem cells in both normal...


Read more at: Deficient methylation and formylation of mt-tRNAMet wobble cytosine in a patient lacking NSUN3
Deficient methylation and formylation of mt-tRNAMet wobble cytosine in a patient lacking NSUN3

Deficient methylation and formylation of mt-tRNAMet wobble cytosine in a patient lacking NSUN3

16 November 2016

New article from the Frye Lab in Nature Communications Mitochondrial disease is a chronic, genetic disorder caused by dysfunctional mitochondria, the organelles that generate energy for cells. Researchers used patient cells to identify a novel mechanism causing mitochondria to fail: Loss-of-function mutations in an enzyme...


Read more at: Anatomy of a decision: mapping early development
Anatomy of a decision: mapping early development

Anatomy of a decision: mapping early development

16 November 2016

A new atlas of gene expression during the earliest stages of life boosts studies of development - new study published in Nature led by CSCI researchers from the Gottgens Lab and the European Bioinformatics Institute (EMBL-EBI). In the first genome-scale experiment of its kind, researchers have gained new insights into how...


Read more at: Scientists identify ‘cell of origin’ in skin cancers
Scientists identify ‘cell of origin’ in skin cancers

Scientists identify ‘cell of origin’ in skin cancers

16 November 2016

Scientists have identified for the first time the ‘cell of origin’ – in other words, the first cell from which the cancer grows – in basal cell carcinoma, the most common form of skin cancer, and followed the chain of events that lead to the growth of these invasive tumours. Until now, there has been intense interest in...


Read more at: Sall4 controls differentiation of pluripotent cells independently of the NuRD complex
Sall4 controls differentiation of pluripotent cells independently of the NuRD complex

Sall4 controls differentiation of pluripotent cells independently of the NuRD complex

16 November 2016

Scientists have identified the function of Sall4, a protein important in early development and a hallmark of many cancers. In their paper, published in Development, they show that Sall4 functions to control gene expression in early embryonic cells, controlling their entry into the neural lineage. It is proposed that Sall4...


Read more at: Breast cancer scientists use innovative 3D imaging to help track cancer cells
Breast cancer scientists use innovative 3D imaging to help track cancer cells

Breast cancer scientists use innovative 3D imaging to help track cancer cells

16 November 2016

New article from SCI Affiliate Christine Watson's Lab published in Nature Communications describes a ground-breaking project which tracked the fate of ‘daughter cells’ to find out how cancer moves around the breast from a single stem cell. The cells of the breast undergo a massive expansion during puberty and with every...


Read more at: Interview with Rick Livesey
Interview with Rick Livesey

Interview with Rick Livesey

16 November 2016

Interview with Rick Livesey about his stem cell 'mini brains' that can help researchers study the progression of Alzheimer's disease in the Sunday Express.