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Professor Tony Green

107-Green-2017Professor Tony Green



Laboratory: Cambridge Institute for Medical Research, Cambridge Biomedical Campus

Departmental Affiliation: Haematology



Tony Green is Professor of Haemato-oncology at the University of Cambridge, Head of the University Department of Haematology and Chair of the Haematology senior staff committee in Addenbrooke's Hospital. 



He trained in medicine at the University of Cambridge and University College Hospital London, subsequently completing his haematology training at the Royal Free Hospital and the University Hospital of Wales, Cardiff.  He gained his PhD in molecular biology at the Imperial Cancer Research Fund in London and subsequently spent a post-doctoral period at the Walter and Eliza Hall Institute in Melbourne as a Hamilton-Fairley Travelling Fellow. 


Professional History

Tony moved to Cambridge in 1991 as a Welcome Trust Senior Fellow and honorary Consultant, was appointed as Head of Department in 2000.  He was elected Fellow of the Academy of Medical Sciences in 2001 and Newton Abraham Visiting Professor at the University of Oxford in 2011. 

Tony Green runs the specialist myeloproliferative disorder clinic at Addenbrooke's Hospital and since 1997 has been chief investigator for the PT-1 suite of international clinical trials in essential thrombocythaemia.  His research interests focus on the management and molecular pathogenesis of the myeloproliferative disorders, with a particular focus on JAK/STAT signalling.  He has published widely (over 160 peer-reviewed papers) with senior-author papers in both clinical and more basic journals including NEJM, Lancet, Blood, Nature, EMBO J, PNAS and Development. In addition he has organized numerous national and international scientific meetings and has given plenary talks at ASH, EHA and multiple national hematology societies. 

Professor Green has been a member of the ESH executive committee since 2003. He was elected Fellow of the Academy of Medical Sciences (2001), Newton Abraham Visiting Professor, University of Oxford (2011), Distinguished Visiting Professor Cancer Science Institute, Singapore (2009-10), Grinberg/Wisch Visiting Professor, Mount Sinai Medical Center, New York (2013), and Clement A Finch Visiting Professor, University of Washington (2015) and President of the European Haematology Association (2015-2017).  



Bloodwise, Wellcome, Cancer Research UK, The Leukaemia and Lyphoma Society, NIHR, Kay Kendall Leukaemia Fund 


External links


850 Green research


Order Matters: By studying patients with somatic mutations of both JAK2 and TET2 we have demonstrated, for the first time in any tumour, that the order in which somatic mutations are acquired influences stem/progenitor cell function and therefore tumour behaviour (Ortmann, C. A., Kent, D. G. et al.  N. Engl. J. Med. 372, (2015); image adapted from Nature Reviews Genetics 16, 193, 2015).



The Green Lab focuses on the mechanisms whereby blood stem cells are subverted during the genesis of haematological malignancies.  Over the past decade we have increasingly concentrated on JAK/STAT signalling which is dysregulated in many cancers and plays a key role in multiple stem cell systems.  In particular we have explored the molecular and cellular pathogenesis of a group of pre-leukaemic disorders, the myeloproliferative neoplasms (MPNs), in studies which have spanned basic, translational and clinical research. The myeloproliferative neoplasms harbour mutations that activate the JAK/STAT pathway, are experimentally tractable and provide a paradigm for the earliest stages of tumorigenesis, inaccessible in other cancers.  We described the MPN "mutational landscape" and identified causal mutations which revolutionised their diagnosis and catalysed development of therapeutically valuable JAK-family tyrosine kinase inhibitors. Our more basic research is illuminating the mechanisms whereby the JAK/STAT pathway regulates diverse aspects of cellular function including chromatin biology, DNA replication, genome-wide transcriptional programs and stem cell fate.  Recent highlights include: identification of calreticulin mutations in most patients with a JAK2-unmutated MPN, thus establishing an unexpected link with endoplasmic reticulum biology; the first demonstration in any cancer that mutation order affects stem and progenitor behaviour, thus influencing clinical presentation, disease outcome and response to therapy; and the description of paradigm-shifting non-canonical mechanisms of JAK/STAT signalling. 


850 Green group 2 1ratio


Group Members

Juliet Aungier, Federico Comoglio, David Flores-Santa-Cruz, Carlos Gonzalez-Arias, Jacob Grinfeld, Tina Hamilton, Thorston Klampfl, Juan Li, Stephen Loughran, Francesca Nice, Thomas Oellerich, Hyun Jung Park, Dean Pask, Daniel Prins, Rachel Sneade, Matthew Williams.


Potential postdocs, clinical fellows and students:

We are always keen to hear from good people. Please email () with a copy of your CV including the details of two referees. 


Plain English

Blood stem cells produce a large number of cell types and are the best studied adult stem cell system. We are interested in the molecular mechanisms that control the formation and behavior of normal blood stem cells and how these processes are perturbed during the development of haematological malignancies. In particular we have focussed on a group of human pre-leukaemic disorders, called the myeloproliferative neoplasms, in studies which span basic, translational and clinical research. Our basic studies are illuminating the fundamental mechanisms by which these disorders arise, and have a broad relevance for other cancers and for the normal process of blood cell formation. Moreover, our results have already had major clinical impact, with new diagnostic approaches embedded in international guidelines and multiple JAK inhibitors in clinical trials. 


Key Publications