Deep Adhya

After completing his PhD at the Department of Psychiatry, Deep showed that the in-vitro neural tube structure, the ‘neural rosette’ is affected in autism induced pluripotent stem cell (iPSC) derived neurons. His work suggested that genetic and epigenetic influences affect atypical iPSC neural differentiation (Adhya et al 2021). He is currently studying chromatin regulators that cause atypical neural rosette formation in autism. Specifically, he is investigating the role of the MLL and FOX family proteins on early neurodevelopment. He plans to establish the effects of the epigenome on neuronal outcomes during development using a 3D brain organoid approach.