Biography
After completing his PhD at the Department of Psychiatry, Deep showed that the in-vitro neural tube structure, the ‘neural rosette’ is affected in autism induced pluripotent stem cell (iPSC) derived neurons. His work suggested that genetic and epigenetic influences affect atypical iPSC neural differentiation (Adhya et al 2021). He is currently studying chromatin regulators that cause atypical neural rosette formation in autism. Specifically, he is investigating the role of the MLL and FOX family proteins on early neurodevelopment. He plans to establish the effects of the epigenome on neuronal outcomes during development using a 3D brain organoid approach.
Publications
Key publications:
- Warrier, Varun, et al. "Genetic correlates of phenotypic heterogeneity in autism." Nature Genetics (2022): 1-12.
- Adhya, Dwaipayan, et al. "Application of Airy beam Light sheet microscopy to examine early neurodevelopmental structures in 3D hiPSC-derived human cortical spheroids." Molecular Autism (2021).
- Adhya, Dwaipayan, et al. "Atypical neurogenesis in induced pluripotent stem cell (iPSC) from autistic individuals." Biological Psychiatry (2021).
- Adhya, D., et al. "Environmental Pressures on Transgenerational Epigenetic Inheritance" The Cambridge Handbook of Evolutionary Perspectives on Human Behavior. Cambridge University Press, 2020. 97-122.
- Massrali, Aicha, et al. "The epigenetics of autism." Chromatin Signaling and Neurological Disorders. Academic Press, 2019. 285-302.
- Adhya, Dwaipayan, et al. "Understanding the role of steroids in typical and atypical brain development: advantages of using a “brain in a dish” approach." Journal of neuroendocrinology 30.2 (2018): e12547.
