Biography
Komal obtained a BSc in Biomedical Sciences and an MSc (By Research) from the University of Central Lancashire (UK). She joined Prof Zilbauer’s group in 2012 and has since gained major experience in human gut organoid culture models. As the Senior Scientist, she leads on all gut organoid related projects in the Zilbauer group including their molecular profiling, generation of frozen stocks and conducting functional assays. She is also the Laboratory Manager for the group.
Publications
Key publications:
- Elmentaite R, Kumasaka N, Roberts K, Fleming A, Dann E, King HW, Kleshchevnikov V, Dabrowska M, Pritchard S, Bolt L, Vieira SF, Mamanova L, Huang N, Perrone F, Goh Kai'En I, Lisgo SN, Katan M, Leonard S, Oliver TRW, Hook CE, Nayak K, et al., 2021. Cells of the human intestinal tract mapped across space and time. Nature. doi: 10.1038/s41586-021-03852-1.
- Gasparetto M, Payne F, Nayak K, et al 2021. Transcription and DNA Methylation Patterns of Blood-Derived CD8+ T Cells Are Associated With Age and Inflammatory Bowel Disease But Do Not Predict Prognosis. Gastroenterology, 160(1):232-244.e7. doi: 10.1053/j.gastro.2020.08.017.
- Elmentaite, R, Ross A, Roberts K, James KR, Ortmann D, Gomes T, Nayak KM, et al 2020. Single-Cell Sequencing of Developing Human Gut Reveals Transcriptional Links to Childhood Crohn's Disease. Dev Cell 55, 771-783 e775, doi:10.1016/j.devcel.2020.11.010.
- Kraiczy J, Nayak KM, Howell KJ, Ross A, Forbester J, Salvestrini C, Mustata R, Perkins S, Andersson-Rolf A, Leenen E, Liebert A, Vallier L, Rosenstiel P, Stegle O, Dougan G, Heuschkel R, Koo BK & Zilbauer M. 2017. DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development. GUT: doi: 10.1136/gutjnl -2017-314817.
- Howell KJ, Kraiczy J, Nayak KM, Gasparetto M, Ross A, Lee C, Mak TN, Koo BK, Kumar N, Lawley T, Sinha A, Rosenstiel P, Heuschkel R, Stegle O, Zilbauer M. 2017. DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome. Gastroenterology pii: S0016-5085(17)36241-8. doi: 10.1053/j.gastro.2017.10.007.
- Kraiczy J, Nayak K, Ross A, Raine T, Mak TN, Gasparetto M, Cario E, Rakyan V, Heuschkel R and Zilbauer M. 2015. Assessing DNA methylation in the developing human intestinal epithelium: potential link to inflammatory bowel disease. Mucosal Immunology: [Epub ahead of print] doi:10.1038/mi.2015.88.
