Biography
Tom completed his PhD in the Zilbauer lab in 2022, where he used patient-derived organoids to study the functional role of IBD-associated DNA methylation changes in the human intestinal epithelium. He now works between the Zilbauer lab and the Milner Therapeutics Institute, where he aims to develop the organoid model as a tool for drug discovery and development, including through their application to drug and gene perturbation screening.
Publications
Castro-Dopico T, Dennison TW, Ferdinand JR, Mathews RJ, Fleming A, Clift D, Stewart BJ, Jing C, Strongili K,
Labzin LI, Monk EJM, Saeb-Parsy K, Bryant CE, Clare S, Parkes M, Clatworthy MR. Anti-commensal IgG Drives
Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis. Immunity. 2019 Apr 16;50(4):1099-
1114.e10. doi: 10.1016/j.immuni.2019.02.006. Epub 2019 Mar 12. PMID: 30876876; PMCID: PMC6477154.
Berry MR, Mathews RJ, Ferdinand JR, Jing C, Loudon KW, Wlodek E, Dennison TW, Kuper C, Neuhofer W,
Clatworthy MR. Renal Sodium Gradient Orchestrates a Dynamic Antibacterial Defense Zone. Cell. 2017 Aug
24;170(5):860-874.e19. doi: 10.1016/j.cell.2017.07.022. Epub 2017 Aug 10. PMID: 28803730.
Lok LSC, Dennison TW, Mahbubani KM, Saeb-Parsy K, Chilvers ER, Clatworthy MR. Phenotypically distinct
neutrophils patrol uninfected human and mouse lymph nodes. Proc Natl Acad Sci U S A. 2019 Sep
7;116(38):19083-19089. doi: 10.1073/pnas.1905054116. Epub 2019 Sep 4. PMID: 31484769; PMCID: PMC6754587.
Castro-Dopico T, Fleming A, Dennison TW, Ferdinand JR, Harcourt K, Stewart BJ, Cader Z, Tuong ZK, Jing C, Lok
LSC, Mathews RJ, Portet A, Kaser A, Clare S, Clatworthy MR. GM-CSF Calibrates Macrophage Defense and
Wound Healing Programs during Intestinal Infection and Inflammation. Cell Rep. 2020 Jul 7;32(1):107857. doi:
10.1016/j.celrep.2020.107857. PMID: 32640223; PMCID: PMC7351110.
Zhang Y, Garcia-Ibanez L, Ulbricht C, Lok LSC, Pike JA, Mueller-Winkler J, Dennison TW, Ferdinand JR, Burnett
CJM, Yam-Puc JC, Zhang L, Alfaro RM, Takahama Y, Ohigashi I, Brown G, Kurosaki T, Tybulewicz VLJ, Rot A,
Hauser AE, Clatworthy MR, Toellner KM. Recycling of memory B cells between germinal center and lymph
node subcapsular sinus supports affinity maturation to antigenic drift. Nat Commun. 2022 May 5;13(1):2460.
doi: 10.1038/s41467-022-29978-y. PMID: 35513371; PMCID: PMC9072412.
